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Genomic and Phylogenetic Characterization of Novel, Recombinant H5N2 Avian Influenza Virus Strains Isolated from Vaccinated Chickens with Clinical Symptoms in China

文献类型： 外文期刊

作者： Xu, Huaiying 1 ; Meng, Fang 2 ; Huang, Dihai 1 ; Sheng, Xiaodan 1 ; Wang, Youling 1 ; Zhang, Wei 1 ; Chang, Weishan 2 ; W 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250100, Shandong, Peoples R China

2.Shandong Agr Univ, Dept Vet Prevent Med, Coll Vet Med, Tai An 271018, Shandong, Peoples R China

3.Shandong Jianmu Biol Pharmaceut Co Ltd, Jinan 250100, Shandong, Peoples R China

4.Ohio Dept Agr, Anim Dis Diagnost Lab, Reynoldsburg, OH 43068 USA

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN： 1999-4915

年卷期： 2015 年 7 卷 3 期

页码：

收录情况： SCI

摘要： Infection of poultry with diverse lineages of H5N2 avian influenza viruses has been documented for over three decades in different parts of the world, with limited outbreaks caused by this highly pathogenic avian influenza virus. In the present study, three avian H5N2 influenza viruses, A/chicken/Shijiazhuang/1209/2013, A/chicken/Chiping/0321/2014, and A/chicken/Laiwu/0313/2014, were isolated from chickens with clinical symptoms of avian influenza. Complete genomic and phylogenetic analyses demonstrated that all three isolates are novel recombinant viruses with hemagglutinin (HA) and matrix (M) genes derived from H5N1, and remaining genes derived from H9N2-like viruses. The HA cleavage motif in all three strains (PQIEGRRRKR/GL) is characteristic of a highly pathogenic avian influenza virus strain. These results indicate the occurrence of H5N2 recombination and highlight the importance of continued surveillance of the H5N2 subtype virus and reformulation of vaccine strains.

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