文献类型： 外文期刊
作者： Zhou, Shiyue 1 ; Liu, Zhengjie 2 ; Song, Jiaoyang 2 ; Chen, Yibao 2 ;
作者机构： 1.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China
2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Peoples R China
关键词： temperate phages; host virulence reduction; biofilm degradation; genetic engineering and modification
期刊名称：CURRENT ISSUES IN MOLECULAR BIOLOGY （ 影响因子：3.1； 五年影响因子：3.3 ）
ISSN： 1467-3037
年卷期： 2023 年 45 卷 2 期
页码：
收录情况： SCI
摘要： In the field of phage applications and clinical treatment, virulent phages have been in the spotlight whereas temperate phages received, relatively speaking, less attention. The fact that temperate phages often carry virulent or drug-resistant genes is a constant concern and drawback in temperate phage applications. However, temperate phages also play a role in bacterial regulation. This review elucidates the biological properties of temperate phages based on their life cycle and introduces the latest work on temperate phage applications, such as on host virulence reduction, biofilm degradation, genetic engineering and phage display. The versatile use of temperate phages coupled with their inherent properties, such as economy, ready accessibility, wide variety and host specificity, make temperate phages a solid candidate in tackling bacterial infections.
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