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Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Healthy Chickens in Shandong, China from 2009 to 2014

文献类型： 外文期刊

作者： Li, Lulu 1 ; Zhao, Xiaonan 1 ; Zhang, Qing 1 ; Luo, Yanbo 1 ; Guo, Genglin 3 ; Hu, Ming 1 ; Chen, Yibao 1 ; Liu, Yuqing 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan 250100, Shandong, Peoples R China

2.Key Lab Livestock & Poultry MultiOm MARA, Jinan, Peoples R China

3.Shandong Acad Agr Sci, Shandong Inst Sericulture, Yantai, Peoples R China

关键词： Escherichia coli; antimicrobial resistance; ESBL; PMQR; PMCR

期刊名称：FOODBORNE PATHOGENS AND DISEASE （ 影响因子：2.8； 五年影响因子：3.2 ）

ISSN： 1535-3141

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Antimicrobial resistance (AMR) is a great threat to animal and public health. Here, we conducted a surveillance of Escherichia coli isolated from healthy chickens during 2009-2014 to identify the characteristics of AMR. A total of 351 (95.64%) E. coli isolates were obtained from 367 healthy chicken fecal samples collected from 6 farms located in Shandong Province, China. The susceptibility to 10 antimicrobials, the prevalence of antibiotic resistance genes (ARGs), phylogenetic clustering, and multilocus sequence typing were evaluated. The isolates exhibited high resistant rates (>95%) to ampicillin, cefotaxime, ciprofloxacin, ceftiofur, and enrofloxacin. The most prevalent ARGs were bla(CTX-M) (36.36%), aac(6 ')-Ib-cr (30.79%), qnrS (29.62%), oqxAB (27%), mcr-1 (15.83%), bla(TEM) (9.09%), qnrC (3.52%), qnrD (0.88%), and qepA (0.29%). Phylogenetic clustering analysis indicated that the most prevalent group was group D (37.89%), followed by group B1 (34.76%), A (24.22%), and B2 (3.13%). Fifty-seven sequence types (STs) were identified among the 124 bla(CTX-M)-positive strains, and the dominant STs were ST354 (13.71%), ST117 (5.65%), ST155, ST2309, and ST2505 (4.84% each). There was a significant association between 17 pairs of AMR phenotypes, 14 pairs of ARGs, and 11 pairs of AMR-ARGs. The strongest association was found between ST602 and qnrC (odds ratios: 22.2). This study implied that E. coli isolated from healthy chickens could potentially serve as a reservoir of AMR and ARGs, and significant associations exist among AMR, ARGs, phylogenetic groups, and STs. Our study highlighted the need for routine surveillance of AMR in healthy chickens, and promoting appropriate antibiotic use and implementing regular monitoring of resistance in broilers are crucial for fostering the development of the poultry industry and safeguarding public health.

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