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Gut microbiota community characteristics and disease-related microorganism pattern in a population of healthy Chinese people

文献类型： 外文期刊

作者： Zhang, Wen 1 ; Li, Juan 1 ; Lu, Shan 1 ; Han, Na 1 ; Miao, Jiaojiao 1 ; Zhang, Tingting 1 ; Qiang, Yujun 1 ; Kong, Yanhua 3 ;

作者机构： 1.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China

2.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

3.China Japan Friendship Hosp, Dept Pulm & Crit Care Med,Ctr Resp Med, Dept Pulm Dis TCM 2,Key Unit SATCM Pneumonopathy, Beijing Key Lab Prevent & Treatment Allerg Dis TC, Beijing 100029, Peoples R China

4.Natl Clin Res Ctr Resp Dis, 2 East Yinghua Rd, Beijing 100029, Peoples R China

5.China Med Univ, Nephrol Dept, Aviat Gen Hosp, Beijing 100012, Peoples R China

6.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Beijing, Peoples R China

7.Zigong Ctr Dis Control & Prevent, Zigong, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2019 年 9 卷

页码：

收录情况： SCI

摘要： China's population accounts for about 1/5th of the world's total population. Owing to differences in environment, race, living habits, and other factors, the structure of the intestinal flora of Chinese individuals is expected to have unique features; however, this has not been thoroughly examined. Here, we collected faecal samples from healthy adults living in three cities of China and investigated their gut microbiome using metagenomics and bioinformatics technology. We found that 11 core bacterial genera were present in all of the Chinese faecal samples; moreover, several patient characteristics (age, region, body mass index, physical exercise, smoking habits, and alcoholic drink, and yogurt consumption) were found to have different effects on the gut microbiome of healthy Chinese people. We also examined the distribution patterns of disease-related microorganisms (DRMs), revealing which DRMs can potentially be used as markers for assessment of health risk. We also developed a program called "Guthealthy" for evaluating the health status associated with the microbiome and DRM pattern in the faecal samples. The microbiota data obtained in this study will provide a basis for a healthy gut microbiome composition in the Chinese population.

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