文献类型： 外文期刊

作者： Sun, Qiang ¹ ; Wang, Yang ³ ; Hulth, Anette ⁴ ; Xiao, Yonghong ⁶ ; Nilsson, Lennart E. ⁷ ; Li, Xuewen ⁸ ; Bi, Zhenwang ⁹ ;

作者机构： 1.Shandong Univ, Ctr Hlth Management & Policy, Jinan, Shandong, Peoples R China

2.Shandong Univ, NHFPC, Key Lab Hlth Econ & Policy Res, Jinan, Shandong, Peoples R China

3.China Agr Univ, Coll Vet Med, Beijing, Peoples R China

4.Publ Hlth Agcy Sweden, Solna, Sweden

5.Karolinska Inst, Dept Publ Hlth Sci Global Hlth Hlth Syst & Policy, Solna, Sweden

6.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou, Zhejiang, Peoples R China

7.Linkopings Univ, Dept Clin & Expt Med, Linkoping, Sweden

8.Shandong Univ, Sch Publ Hlth, Dept Environm & Hlth, Jinan, Shandong, Peoples R China

9.Shandong Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China

10.Shandong Prov Key Lab Infect Dis Control & Preven, Jinan, Shandong, Peoples R China

11.Shandong Acad Agr Sci, Jinan, Shandong, Peoples R China

12.Key Lab Anim Epidem Prevent & Breeding Shandong P, Jinan, Shandong, Peoples R China

13.Hebei Prov Ctr Dis Control & Prevent, Shijiazhuang, Hebei, Peoples R China

14.Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Med Sch, Nanjing, Jiangsu, Peoples R China

15.Natl Food Agcy, Risk & Benefit Assessment Dept, Uppsala, Sweden

16.Natl Vet Inst, Uppsala, Sweden

期刊名称：BMJ OPEN （ 影响因子：2.692； 五年影响因子：3.424 ）

ISSN： 2044-6055

年卷期： 2018 年 8 卷 1 期

页码：

收录情况： SCI

摘要： Introduction To effectively minimise the emergence and dissemination of antibiotic resistant bacteria, a holistic One Health approach is called for. The Sino-Swedish Integrated Multisectoral Partnership for Antibiotic Resistance Containment is a cross-sectoral and integrated project on antibiotic resistance, conducted in Shandong Province in China. This paper outlines the overall study protocol for the project. To our knowledge, this is the first research programme aiming to take a true holistic approach across multiple sectors simultaneously in China, and the first to incorporate both antibiotic use and infection prevention and control in addition to antibiotic resistance patterns. The project aims to address gaps in current knowledge and seeks to improve the situation through a system-wide intervention. By using a One Health approach we can address important research questions that individual discipline investigations are unable to. The results obtained should thus more closely reflect the world in which human health, animal health and the environment are inextricably and intimately interlinked. Methods and analysis Both quantitative and qualitative studies are included for households from 12 villages, their surrounding environment and a tertiary care hospital in a nearby town. The studies include analyses of antibiotic consumption for humans and pigs; qualitative and quantitative data on perceptions, knowledge and attitudes; faecal carriage of extended spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae from pigs and humans, and occurrence in household drinking water, surface water, waste water and clinical bacterial isolates from the hospital. Carriage of methicillin-resistant Staphylococcus aureus in humans, household pigs and clinical bacterial isolates is also investigated. Furthermore, potential inter-relationships between these sources are analysed. A multifaceted One Health intervention is designed and implemented in 6 of the 12 villages. Repeated and continuous data collections take place over 2 years, where the repeated data collection is performed after 1 year of intervention. Comparisons are made between intervention and control villages, before and after the intervention. Ethics Ethics approval was obtained from the first Affiliated Hospital, College of Medicine, Zhejiang University, China, reference number 2015#185 and 20154283.