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O145 may be emerging as a predominant serogroup of Avian pathogenic Escherichia coli (APEC) in China

文献类型： 外文期刊

作者： Wang, Zhuohao 1 ; Zheng, Xiangkuan 1 ; Guo, Genglin 1 ; Hu, Zimeng 1 ; Miao, Jinfeng 1 ; Dong, Yongyi 4 ; Xu, Zhengjun 4 ; Zhou, Qingan 5 ; Wei, Xiankai 5 ; Han, Xiangan 6 ; Liu, Yuqing 7 ; Zhang, Wei 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

2.Minist Agr, Key Lab Anim Bacteriol, Nanjing 210095, Peoples R China

3.OIE Reference Lab Swine Streptococcosis, Nanjing 210095, Jiangsu, Peoples R China

4.Prevent & Control Ctr Jiangsu Prov, Lab Anim Dis, Nanjing 210009, Jiangsu, Peoples R China

5.Guangxi Ctr Anim Dis Control & Prevent, Nanning 530001, Guangxi, Peoples R China

6.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

7.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250108, Shandong, Peoples R China

关键词： Avian pathogenic Escherichia coli (APEC); O145; Serogrouping; Virulence evaluation; Non-O157 Shiga toxin-producing Escherichia coli; Pangenome

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2022 年 266 卷

页码：

收录情况： SCI

摘要： Among the numerous serotypes of Avian pathogenic Escherichia coli (APEC), O1, O2 and O78 have long been considered the predominant serogroups. O145, a pivotal serogroup in non-O157 Shiga toxin-producing Escherichia coli, has never been considered an important serogroup among APEC.The prevalence of APEC O145 was determined from the results of molecular serogrouping based on 42 sequenced isolates from Jiangsu and Guangxi Provinces in China. After realizing the potential importance of O145, 224 APEC isolates isolated from Jiangsu, Guangxi, Anhui, Shandong, Henan, Yunnan and Fujian provinces were screened using PCR amplification. The results showed that the proportion of O145 detected was 37.9 % (85/224), which was higher than those of the three traditional APEC serogroups. The virulence evaluation experiment showed that this serogroup may have stronger pathogenicity. Here, we report for the first time that O145 may be emerging as a predominant serogroup of APEC in China. The possible reasons for its prevalence and oversight were analyzed through genomic analysis. Furthermore, pangenome analysis with STEC O145 was performed to assess the potential threat to humans.The discovery of the ubiquity of O145 may not be coincidental, which may also account for the failure of vaccines that target the three major serogroups. Therefore, this newly predominant serogroup should be paid more attention and the focus should not be limited to the so-called three major APEC serogroups.

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