您好，欢迎访问山东省农业科学院文献资源数据库平台

Novel single nucleotide polymorphisms (SNPs) of the bovine STAT4 gene and their associations with production traits in Chinese Holstein cattle

文献类型： 外文期刊

作者： Zhang, Fenfen 1 ; Huang, Jinming 2 ; Li, Qiuling 2 ; Ju, Zhihua 2 ; Li, Jiangbin 2 ; Shi, Fangxiong 1 ; Zhong, Jifeng; 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China

2.Shandong Acad Agr Sci, Dairy Cattle Sci Res Ctr, Jinan 250100, Shandong, Peoples R China

关键词： Dairy cattle;STAT4 gene;SNP;milk production traits

期刊名称：AFRICAN JOURNAL OF BIOTECHNOLOGY （ 影响因子：0.573； 五年影响因子：0.794 ）

ISSN： 1684-5315

年卷期： 2010 年 9 卷 26 期

页码：

收录情况： SCI

摘要： Signal transducer and activator of transcription 4 (STAT4) belongs to the STATs family which may play important roles in the activation of milk protein genes and the development of mammary glands. Four novel single nucleotide polymorphisms (SNPs) (g. 2624A>C ss175327225, g. 60330A>G ss175327226, g. 63823G>C ss175327227, g. 66912C>T ss175327228) of the STAT4 gene were investigated in 966 cattle of three breeds (Chinese holstein, Luxi yellow and Bohai black cattle) in China by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP), PCR-restriction fragment length polymorphism (RFLP) and DNA sequencing methods. The SNP (g. 60330A>G ss175327226) could be genotyped into three genotypes (AA, AG and GG) with PCR-RFLP using Msp I and another SNP (g. 66912C>T ss175327228) only into two genotypes (CC and TC) by PCR-SSCP. The allelic frequencies of the SNP (g. 60330A>G) were different among the three different cattle breeds (P < 0.05). The associations between polymorphisms of the STAT4 gene and dairy performance traits were analyzed in 793 Chinese holstein cows. The SNP (g. 60330A>G) markedly affected the 305 d matured equivalency (P < 0.05) and fat content (P < 0.05). However, the SNP (g. 66912C>T) had no significant relationship with the milk production traits (P > 0.05). Together, the SNP (g. 60330A>G) of the STAT4 gene may serve as a molecular marker for the differentiation of various cattle populations and selection of the milk yield and fat content in bovine breeding program.

  • 相关文献

[1]Correlation analysis between three novel SNPs of the Src gene in bovine and milk production traits. Liu, Wenyan,Wang, Ji,Li, Qiuling,Ju, Zhihua,Huang, Jinming,Wang, Hongmei,Li, Jianbin,Zhong, Jifeng,Wang, Changfa,Liu, Wenyan,Liu, Shunde.

[2]Molecular cloning, promoter analysis, SNP detection of Clusterin gene and their associations with mastitis in Chinese Holstein cows. Wang, Zeying,Wang, Genlin,Huang, Jingmin,Zhong, Jifeng.

[3]Three novel SNPs of the bovine Tf gene in Chinese native cattle and their associations with milk production traits. Ju, Z. H.,Li, Q. L.,Huang, J. M.,Hou, M. H.,Li, R. L.,Li, J. B.,Zhong, J. F.,Wang, C. F.. 2011

[4]The polymorphisms of kappa-casein gene and their associations with milk production traits and expression analysis in Chinese Holstein cattle. Ju, Zhihua,Huang, Jinming,Li, Qiuling,Wang, Hongmei,Zhong, Jifeng,Wang, Changfa. 2011

[5]Single nucleotide polymorphisms, haplotypes and combined genotypes of LAP3 gene in bovine and their association with milk production traits. Zheng, Xue,Ju, Zhihua,Wang, Ji,Li, Qiuling,Huang, Jinming,Zhong, Jifeng,Wang, Changfa,Zheng, Xue,Zhang, Aiwu. 2011

[6]Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle. Yang, Y.,Huang, J. M.,Ju, Z. H.,Li, Q. L.,Zhou, L.,Li, R. L.,Li, J. B.,Zhong, J. F.,Wang, C. F.,Yang, Y.,Shi, F. X.,Yang, Y.. 2012

[7]Two splice variants of the bovine lactoferrin gene identified in Staphylococcus aureus isolated from mastitis in dairy cattle. Huang, J. M.,Wang, Z. Y.,Ju, Z. H.,Wang, C. F.,Li, Q. L.,Sun, T.,Hou, Q. L.,Hang, S. Q.,Hou, M. H.,Zhong, J. F.. 2011

[8]A SNP in the 3 '-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484. Li, Q. L.,Xia, P.,Wang, Y. J.,Wu, Z. Y.,Jia, Y. H.,Chang, S. M.,Zhang, Z. F.,Li, Q. L.,Chu, M. X.. 2015

[9]The exon 29 c.3535A > T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle. Wang, Xiuge,Huang, Jinming,Zhao, Lihong,Wang, Changfa,Ju, Zhihua,Li, Qiuling,Qi, Chao,Zhang, Yan,Zhang, Zebin,Zhang, Wei,Hou, Minghai,Zhong, Jifeng,Wang, Xiuge,Yuan, Jinduo,Zhao, Lihong. 2012

[10]Single nucleotide polymorphisms, haplotypes and combined genotypes of lactoferrin gene and their associations with mastitis in Chinese Holstein cattle. Huang, Jinming,Wang, Hongmei,Wang, Changfa,Li, Jianbin,Li, Qiuling,Hou, Minghai,Zhong, Jifeng.

[11]Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of the BOLA-DQA2 Gene in Dairy Cattle. Hou, Qinlei,Huang, Jinming,Ju, Zhihua,Li, Qiuling,Li, Liming,Wang, Changfa,Sun, Tao,Wang, Lingling,Hou, Minghai,Zhong, Jifeng,Hang, Suqin.

[12]One SNP in the 3'-UTR of HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis in dairy cattle. Li, Liming,Huang, Jinming,Ju, Zhihua,Qi, Chao,Zhang, Yan,Li, Qiuling,Wang, Changfa,Miao, Weiran,Zhong, Jifeng,Hou, Minghai,Zhang, Xiaojian,Hang, Suqin. 2012

[13]Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in Holstein Cattle. Huang, Jinming,Ju, Zhihua,Li, Qiuling,Hou, Qinlei,Wang, Changfa,Li, Jianbin,Li, Rongling,Wang, Lingling,Sun, Tao,Hang, Suqin,Gao, Yundong,Hou, Minghai,Zhong, Jifeng.

[14]花生杂种分子鉴定和ahFAD2基因分型技术研究进展. 袁美,王传堂,韩锁义,任艳,尹亮,石延茂,徐平,王效华,李双铃,郑奕雄. 2017

[15]INCENP基因功能性单倍型可调控启动子活性并影响公牛精液品质. 刘娟,孙艳,姜强,杨春红,黄金明,李建斌,侯明海,仲跻峰,王长法. 2016

[16]利用特异性SNP位点鉴定花生杂交F_1代真假杂种. 韩燕,马登超,刘译阳,崔凤,孙秀芹,李荣冲,万书波,李国卫. 2016

[17]牛MC1R基因——新的SNP. 甘海云,张秀红,李景鹏. 2007

[18]MC1R基因多态性与杜黑猪毛色关系研究. 巩静,杨晴,王艺盼,王彦平,朱晓东,张传生,耿立英,王继英. 2023

[19]GALNTL5对精子发生的影响. 李虹,鞠志花,崔晓慧,姜强,孙艳,杨春红,杨桂文,王长法. 2016

[20]GenBank中花生栽培种基因组DNA及EST序列的SNP分析. 唐月异,张建成,王秀贞,崔凤高,王传堂. 2010

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台