您好，欢迎访问山东省农业科学院文献资源数据库平台

Signatures of selection in indigenous Chinese cattle genomes reveal adaptive genes and genetic variations to cold climate

文献类型： 外文期刊

作者： Huang, Ning 1 ; Zhao, Lihong 4 ; Wang, Jinpeng 1 ; Jiang, Qiang 1 ; Ju, Zhihua 1 ; Wang, Xiuge 2 ; Yang, Chunhong 1 ; Gao, Yaping 1 ; Wei, Xiaochao 1 ; Zhang, Yaran 2 ; Xiao, Yao 2 ; Liu, Wenhao 2 ; Lu, Shaoxiong 3 ; Huang, Jinming 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Key Lab Livestock & Poultry Multiom MARA, Jinan, Peoples R China

2.Shandong Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China

3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming, Peoples R China

4.Shandong Acad Agr Sci, SAAMS, Informat Ctr, Jinan, Peoples R China

关键词： adaptive allele; cattle; cold adaptation; selective sweep; thermogenesis

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：3.3； 五年影响因子：3.1 ）

ISSN： 0021-8812

年卷期： 2023 年 101 卷

页码：

收录情况： SCI

摘要： This study provides novel insights into genetic adaptations to cold environments in indigenous Chinese cattle. Lay Summary Cold climates can affect cattle performance, survival, and health. Local cattle breeds have been adapted to the local environments including extremely cold temperatures after a long period of natural and artificial selection. Selection and local adaptation are shaping populations. However, identifying loci associated with cold adaptation has been a major challenge. We used high-density SNP arrays and resequencing data to comprehensively analyze and compare the genomic selection signatures of Chinese northern and southern cattle, and elucidated several adaptive genes and alleles involved in cold adaptation. The complexity of genetic adaptation mechanism among different low-temperature adapted cattle breeds was also emphasized. Cold climate shapes the genome of animals and drives them to carry sufficient genetic variations to adapt to changes in temperature. However, limited information is available about the genome-wide pattern of adaptations to cold environments in cattle. In the present study, we used 777K SNP genotyping (15 Chinese cattle breeds, 198 individuals) and whole genome resequencing data (54 cattle breeds of the world, 432 individuals) to disentangle divergent selection signatures, especially between the cold-adapted (annual average temperature of habitat, 6.24 degrees C to 10.3 degrees C) and heat-adapted (20.2 degrees C to 24.73 degrees C) Chinese native cattle breeds. Genomic analyses revealed a set of candidate genes (e.g., UQCR11, DNAJC18, EGR1, and STING1) were functionally associated with thermogenesis and energy metabolism. We also characterized the adaptive loci of cattle exposed to cold temperatures. Our study finds new candidate genes and provides new insights into adaptations to cold climates in cattle.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台