文献类型： 外文期刊
作者： Jiang, Qiang 1 ; Wang, Yongsheng 3 ; Xiang, Minghui 1 ; Hua, Jiamin 1 ; Zhou, Tianci 1 ; Chen, Fanghui 4 ; Lv, Xiaoyang 5 ; Huang, Jinming 2 ; Cai, Yafei 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Dept Anim Genet Breeding & Reprod, Nanjing, Peoples R China
2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Peoples R China
3.Nanjing Univ, Dept Resp Med, Nanjing Drum Tower Hosp, Med Sch, Nanjing, Peoples R China
4.Emory Univ, Dept Hematol & Med Oncol, Sch Med, Atlanta, GA USA
5.Int Joint Res Lab Univ Jiangsu Prov China Domest A, Yangzhou, Peoples R China
关键词： UFL1; Ufmylation modification; ER stress; genotoxic stress; oncogenic stress; inflammation
期刊名称：FRONTIERS IN ENDOCRINOLOGY （ 影响因子：5.2； 五年影响因子：5.9 ）
ISSN： 1664-2392
年卷期： 2023 年 14 卷
页码：
收录情况： SCI
摘要： The UFM1 conjugation system(UFMylation)is a novel type of ubiquitin-like system that plays an indispensable role in maintaining cell homeostasis under various cellular stress. Similar to ubiquitination, UFMylation consists of a three-step enzymatic reaction with E1-like enzymes ubiquitin-like modifier activating enzyme5 (UBA5), E2-like enzymes ubiquitin-fold modifier-conjugating enzyme 1(UFC1), and E3-like ligase UFM1-specific ligase 1 (UFL1). As the only identified E3 ligase, UFL1 is responsible for specific binding and modification of the substrates to mediate numerous hormone signaling pathways and endocrine regulation under different physiological or pathological stress, such as ER stress, genotoxic stress, oncogenic stress, and inflammation. Further elucidation of the UFL1 working mechanism in multiple cellular stress responses is essential for revealing the disease pathogenesis and providing novel potential therapeutic targets. In this short review, we summarize the recent advances in novel UFL1 functions and shed light on the potential challenges ahead, thus hopefully providing a better understanding of UFMylation-mediated cellular stress.
- 相关文献
作者其他论文 更多>>
-
CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice
作者：Wei, Xiaochao;Wang, Xiuge;Yang, Chunhong;Gao, Yaping;Zhang, Yaran;Xiao, Yao;Ju, Zhihua;Jiang, Qiang;Wang, Jinpeng;Liu, Wenhao;Li, Yanqin;Gao, Yundong;Huang, Jinming;Wei, Xiaochao;Wang, Xiuge;Yang, Chunhong;Gao, Yaping;Zhang, Yaran;Xiao, Yao;Ju, Zhihua;Jiang, Qiang;Wang, Jinpeng;Liu, Wenhao;Li, Yanqin;Gao, Yundong;Huang, Jinming;Gao, Yundong;Huang, Jinming
关键词：CFAP58; Genetic variation; Spermatogenesis; Manchette; IMT/IFT
-
Characterizing the hindgut microbiome in healthy and ketotic cows
作者：Ju, Zhihua;Li, Rongling;Liu, Wenhao;Jiang, Qiang;Wang, Jinpeng;Zhang, Yaran;Wang, Xiuge;Xiao, Yao;Yang, Chunhong;Wei, Xiaochao;Gao, Yaping;Huang, Jinming;Ju, Zhihua;Li, Rongling;Liu, Wenhao;Wang, Jinpeng;Zhang, Yaran;Wang, Xiuge;Xiao, Yao;Huang, Jinming;Ju, Zhihua;Huang, Jinming
关键词：Cow ketosis; beta-hydroxybutyrate; 16S sequencing; hindgut fecal microbiota
-
Evolutionary adaptations generally reverse phenotypic plasticity to restore ancestral phenotypes during new environment adaptation in cattle
作者：Jiang, Qiang;Cai, Yafei;Jiang, Qiang;Huang, Jinming;Zhu, Li;Zeng, Hao;Basang, Zhuzha;Suolang, Quji
关键词：cattle; environment adaptation; gene expression; phenotypic plasticity
-
Coordinated alternation of DNA methylation and alternative splicing of PBRM1 affect bovine sperm structure and motility
作者：Yang, Chunhong;Xiao, Yao;Wang, Xiuge;Wei, Xiaochao;Wang, Jinpeng;Gao, Yaping;Jiang, Qiang;Ju, Zhihua;Zhang, Yaran;Liu, Wenhao;Huang, Ning;Li, Yanqin;Gao, Yundong;Wang, Lingling;Huang, Jinming;Yang, Chunhong;Xiao, Yao;Wang, Xiuge;Wei, Xiaochao;Wang, Jinpeng;Gao, Yaping;Jiang, Qiang;Ju, Zhihua;Zhang, Yaran;Liu, Wenhao;Huang, Ning;Li, Yanqin;Gao, Yundong;Wang, Lingling;Huang, Jinming;Ju, Zhihua;Huang, Jinming;Huang, Jinming
关键词：Alternative splicing; dairy cattle; epigenetic regulation; PBRM1; spermatogenesis
-
Signatures of selection in indigenous Chinese cattle genomes reveal adaptive genes and genetic variations to cold climate
作者：Huang, Ning;Wang, Jinpeng;Jiang, Qiang;Ju, Zhihua;Huang, Jinming;Huang, Ning;Wang, Jinpeng;Ju, Zhihua;Wang, Xiuge;Zhang, Yaran;Xiao, Yao;Liu, Wenhao;Huang, Jinming;Huang, Ning;Lu, Shaoxiong;Zhao, Lihong
关键词：adaptive allele; cattle; cold adaptation; selective sweep; thermogenesis
-
Identification of target genes and pathways related to heat tolerance in Chinese Holstein cows
作者：Li, Rongling;Ahmad, Muhammad Jamil;Yang, Liguo;Li, Rongling;Hou, Minghai;Wang, Xiao;Li, Jianbin;Jiang, Qiang;Huang, Jinming;Liu, Shenhe
关键词：Dairy cows; Heat stress; miRNAs; RNA sequencing; Temperature-humidity index
-
A Novel TLR4-SYK Interaction Axis Plays an Essential Role in the Innate Immunity Response in Bovine Mammary Epithelial Cells
作者：Yang, Fan;Yuan, Lu;Xiang, Minghui;Jiang, Qiang;Zhang, Manling;Chen, Fanghui;Cai, Yafei;Yang, Fan;Tong, Jie;Yang, Fan;Huang, Jinming
关键词：TLR4-SYK interaction axis; mastitis; bMECs; dairy cattle
