您好，欢迎访问山东省农业科学院文献资源数据库平台

Novel single nucleotide polymorphisms (SNPs) of the bovine STAT4 gene and their associations with production traits in Chinese Holstein cattle

文献类型： 外文期刊

作者： Zhang, Fenfen 1 ; Huang, Jinming 2 ; Li, Qiuling 2 ; Ju, Zhihua 2 ; Li, Jiangbin 2 ; Shi, Fangxiong 1 ; Zhong, Jifeng 2 ; Wang, Changfa 2 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China

2.Shandong Acad Agr Sci, Dairy Cattle Sci Res Ctr, Jinan 250100, Shandong, Peoples R China

关键词： Dairy cattle; STAT4 gene; SNP; milk production traits

期刊名称：AFRICAN JOURNAL OF BIOTECHNOLOGY （ 影响因子：0.573； 五年影响因子：0.794 ）

ISSN： 1684-5315

年卷期： 2010 年 9 卷 26 期

页码：

收录情况： SCI

摘要： Signal transducer and activator of transcription 4 (STAT4) belongs to the STATs family which may play important roles in the activation of milk protein genes and the development of mammary glands. Four novel single nucleotide polymorphisms (SNPs) (g. 2624A>C ss175327225, g. 60330A>G ss175327226, g. 63823G>C ss175327227, g. 66912C>T ss175327228) of the STAT4 gene were investigated in 966 cattle of three breeds (Chinese holstein, Luxi yellow and Bohai black cattle) in China by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP), PCR-restriction fragment length polymorphism (RFLP) and DNA sequencing methods. The SNP (g. 60330A>G ss175327226) could be genotyped into three genotypes (AA, AG and GG) with PCR-RFLP using Msp I and another SNP (g. 66912C>T ss175327228) only into two genotypes (CC and TC) by PCR-SSCP. The allelic frequencies of the SNP (g. 60330A>G) were different among the three different cattle breeds (P < 0.05). The associations between polymorphisms of the STAT4 gene and dairy performance traits were analyzed in 793 Chinese holstein cows. The SNP (g. 60330A>G) markedly affected the 305 d matured equivalency (P < 0.05) and fat content (P < 0.05). However, the SNP (g. 66912C>T) had no significant relationship with the milk production traits (P > 0.05). Together, the SNP (g. 60330A>G) of the STAT4 gene may serve as a molecular marker for the differentiation of various cattle populations and selection of the milk yield and fat content in bovine breeding program.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台