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Macrophage immunomodulatory activity of polysaccharides isolated from Glycyrrhiza uralensis fish

文献类型： 外文期刊

作者： Cheng, Anwei 1 ; Wan, Fachun 2 ; Wang, Jiaqi 3 ; Jin, Zhengyu 1 ; Xu, Xueming 1 ;

作者机构： 1.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China

2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Peoples R China

3.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100094, Peoples R China

关键词： Glycyrrhiza uralensis fish;polysaccharides;immunomodulator;macrophage;cytokine

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2008 年 8 卷 1 期

页码：

收录情况： SCI

摘要： The objective of this study was to evaluate the immunomodulatory effects of the purified glycyrrhiza polysaccharides (GP) on the activity of macrophages. A purified fraction of water-soluble polysaccharides, with estimated molecular weight of 10 kDa, was isolated from Glycyrrhiza uralensis Fish using ion exchange and size exclusion chromatography. The results indicate that GP increased the pinocytic activity, the production of nitric oxide (NO), interteukin-1 (IL-1), IL-6 and IL-12 in a dose-dependent manner. The production of IL-1 was induced by GP at a dose of 10 mu g/mL; but, NO, IL-6 and IL-12 was significantly induced at 100 mu g/mL. A time-dependent enhancement showed that the production of IL-1, NO and IL-12 were significantly increased within 6 h. Superoxide anion (O ((2)) over bar) production by macrophages from GP-treated mice was higher than that of cells from untreated mice. Moreover, cells from both untreated and treated mice responded to phorbol 12-myristate 13-acetate (PMA) treatment; however, the O ((2)) over bar production was higher in the cells from treated mice than that of cells from untreated mice. Our data suggest that the beneficial therapeutic effects of GP may be attributed partly to its ability to modulate macrophage immune functions. (C) 2007 Published by Elsevier B.V.

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[1]Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch. Cheng, Anwei,Jin, Zhengyu,Xu, Xueming,Wan, Fachun,Wang, Jiaqi. 2008

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