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Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells

文献类型： 外文期刊

作者： Zhang, Xianglun 1 ; Liu, Xiaomu 1 ; Wan, Fachun 1 ; You, Wei 1 ; Tan, Xiuwen 1 ; Sheng, Qingkai 1 ; Li, Chuanhao 1 ; Hu, Zhuran 3 ; Liu, Guifen 1 ; Zhao, Hongbo 1 ;

作者机构： 1.Shandong Acad Agr Sci, Shandong Key Lab Anim Dis Control & Breeding, Anim Sci & Vet Med Inst, Jinan, Peoples R China

2.Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China

3.Shandong Green & Blue Biotechnol Co Ltd, Tai An, Shandong, Peoples R China

关键词： Resveratrol; Beef quality; Bovine skeletal muscle cell; Oxidative stress; Antioxidant

期刊名称：MEAT SCIENCE （ 影响因子：7.077； 五年影响因子：6.632 ）

ISSN： 0309-1740

年卷期： 2022 年 185 卷

页码：

收录情况： SCI

摘要： The objective of this study was to investigate the protective effects and the underlying mechanisms of resveratrol (RES) against hydrogen peroxide (H2O2)-induced oxidative stress in bovine skeletal muscle cells (BMCs). Pretreatment of BMCs with RES prior to H2O2 exposure increased cell viability, attenuated reactive oxygen species, and stabilized the redox state. H2O2 exposure activated sirtuin type 1 (SIRT1) and nuclear factor E2-related factor 2 (NRF2)-mediated signaling pathways. Pretreatment with RES did not alter SIRT1-regulated genes but inhibited the upregulation of NRF2, whereas enhanced heme oxygenase 1 (HO-1) expression. Pretreatment with RES prior to H2O2 exposure failed to suppress NRF2 expression when NRF2 was knocked down by RNA interference. However, HO-1 expression still could be induced by RES. These results suggest that RES has benifical effects against oxidative stress. NRF2-mediated pathway play an important role, and HO-1 upregulation is the key process in RES regulation. RES may be used as a therapeutic agent for meat quality improvement in beef cattle.

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