Extractable and non-extractable polyphenols from blueberries modulate LPS-induced expression of iNOS and COX-2 in RAW264.7 macrophages via the NF-kappa B signalling pathway
文献类型： 外文期刊
作者： Cheng, Anwei 1 ; Han, Caijing 1 ; Fang, Xixiu 2 ; Sun, Jinyue 1 ; Chen, Xiangyan 1 ; Wan, Fachun 3 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
2.Jiangsu Agr & Anim Husb Coll, Nutr & Biotechnol Res Ctr, Taizhou 225300, Peoples R China
3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Peoples R China
4.Key Lab Agr Prod Deep Proc Technol Shandong, Jinan, Shandong, Peoples R China
关键词： extractable polyphenols;non-extractable polyphenols;inducible nitric oxide synthase;cyclooxygenase-2;nuclear factor-kappa B
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：3.638； 五年影响因子：3.802 ）
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收录情况： SCI
摘要： BACKGROUND: Plant polyphenols are rich in blueberries that have a wide range of properties beneficial to human health. There are two types, according to the solubility of polyphenols, which were defined as extractable polyphenols (EPP) and non-extractable polyphenols (NEPP), respectively. At present, inmost of reports, 'total polyphenol' refers only to EPP excluding NEPP. In this paper, the effects of EPP and NEPP on lipopolysaccharides (LPS) induced production of nitric oxide (NO) and gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW264.7 cells via nuclear factor-kappa B (NF-kappa B) signalling pathway were compared.
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