Evaluating the hypolipidemic effect of garlic essential oil encapsulated in a novel double-layer delivery system
文献类型： 外文期刊
作者： Zhang, Xueli 1 ; Guo, Xu 2 ; Sun, Jinyue 2 ; Chen, Yingying 2 ; Zhang, Mengqi 2 ; Tang, Xiaozhen 1 ; Wang, Wenliang 2 ; Simal-Gandara, Jesus 4 ; Xu, Huiying 5 ; Li, Ningyang 3 ; Liu, Chao 2 ;
作者机构： 1.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Peoples R China
2.Shandong Acad Agr Sci, Minist Agr & Rural Affairs, Inst Agrofood Sci & Technol, Key Lab Novel Food Resources Proc,Key Lab Agroprod, 23788 Gongye North Rd, Jinan 250100, Peoples R China
3.Ocean Univ China, Coll Food Sci & Engn, Qingdao 266003, Peoples R China
4.Univ Vigo, Fac Sci, Dept Analyt Chem & Food Sci, Nutr & Bromatol Grp, E-32004 Orense, Spain
5.Heze Municipal Bur Nat Resources & Planning, Heze 274000, Peoples R China
关键词： Garlic essential oil; Cyclodextrin inclusion complex liposome; delivery system; Characterization; Stability; Lowering blood lipid
期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.8； 五年影响因子：5.4 ）
ISSN： 0927-7765
年卷期： 2024 年 237 卷
页码：
收录情况： SCI
摘要： The limited application of garlic essential oil (GEO) is attributed to its pungent taste, poor water solubility and low bioavailability. Liposomes are nontoxic, biodegradable and biocompatible, and beta -cyclodextrin can inhibit undesirable odors and improve the stability and bioavailability. Thus a promising dual -layer GEO beta -cyclodextrin inclusion compound liposome (GEO-DCL) delivery system with both advantages was designed and prepared in this study. Experimental results indicated that the encapsulation efficiency of GEO-DCLs was 5% higher than that of GEO liposomes (GEO-CLs), reaching more than 88%. In vitro release experiment showed that the release rate of GEO in GEO-DCLs was 40% lower than that of GEO-CLs after incubation in gastric juice for 6-h, indicating that the stability of GEO-DCLs was better than GEO-CLs. Evaluation of the effects of GEO-DCLs on lowering blood lipid levels in hypercholesterolemia mice. GEO-DCLs could reduce the weight and fat deposition in hypercholesterolemia mice. Inhibiting the increase of TC, LDL-C, and decrease of HDL-C in mice. The degree of liver injury was decreased, the number of round lipid droplets in liver cytoplasm was reduced, and the growth of fat cells was inhibited. The lipid -lowering effects of GEO-DCLs were dose -dependent. GEO-DCL can improve the bioavailability of GEO and improve dyslipidemia. Based on GEO ' s efficacy in lowering blood lipids, this study developed a kind of GEO-DCL compound pomegranate juice beverage with good taste, miscibility and double effect of reducing blood lipids. This study lays a foundation for the application of GEO in the field of functional food.
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