Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish
文献类型： 外文期刊
作者： Xin, Shaoshuai 1 ; Zhang, Mengqi 2 ; Li, Peihai 1 ; Wang, Lizhen 1 ; Zhang, Xuanming 1 ; Zhang, Shanshan 1 ; Mu, Zhenqiang 3 ; Lin, Houwen 5 ; Li, Xiaobin 1 ; Liu, Kechun 1 ;
作者机构： 1.Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan 250103, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Agroprod Proc Technol Shandong Prov, Key Lab Novel Food Resources Proc,Minist Agr & Rur, 23788 Gongye North Rd, Jinan 250100, Peoples R China
3.Chongqing Med & Pharmaceut Coll, Chongqing Key Lab High Active Traditional Chinese, Chongqing 410331, Peoples R China
4.Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 410331, Peoples R China
5.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Res Ctr Marine Drugs, Sch Med,Dept Pharm, Shanghai 200127, Peoples R China
关键词： marine-derived fungus; 4-hydroxyphenylacetic acid; antithrombotic; autophagy
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN：
年卷期： 2024 年 22 卷 4 期
页码：
收录情况： SCI
摘要： Marine natural products are important sources of novel drugs. In this study, we isolated 4-hydroxyphenylacetic acid (HPA) from the marine-derived fungus Emericellopsis maritima Y39-2. The antithrombotic activity and mechanism of HPA were reported for the first time. Using a zebrafish model, we found that HPA had a strong antithrombotic activity because it can significantly increase cardiac erythrocytes, blood flow velocity, and heart rate, reduce caudal thrombus, and reverse the inflammatory response caused by Arachidonic Acid (AA). Further transcriptome analysis and qRT-PCR validation demonstrated that HPA may regulate autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to exert antithrombotic effects.
- 相关文献
作者其他论文 更多>>
-
Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification
作者：Li, Peihai;Wang, Dexu;Yang, Xueliang;Liu, Changyu;Li, Xiaobin;Zhang, Xuanming;Liu, Kechun;Zhang, Yun;Wang, Rongchun;Zhang, Mengqi;Wang, Changyun
关键词：silibinin; anti-tumor; network pharmacology; adenoid cystic carcinoma; Western blot analysis
-
Evaluating the hypolipidemic effect of garlic essential oil encapsulated in a novel double-layer delivery system
作者：Zhang, Xueli;Tang, Xiaozhen;Zhang, Xueli;Guo, Xu;Sun, Jinyue;Chen, Yingying;Zhang, Mengqi;Wang, Wenliang;Liu, Chao;Li, Ningyang;Simal-Gandara, Jesus;Xu, Huiying
关键词：Garlic essential oil; Cyclodextrin inclusion complex liposome; delivery system; Characterization; Stability; Lowering blood lipid
-
Extraction, purification and anticancer activity studies on triterpenes from pomegranate peel
作者：Zhang, Mengqi;Zhang, Yutao;Guo, Xu;Chen, Yingying;Sun, Shutao;Ren, Qidong;Sun, Jinyue;Liu, Chao;Zhang, Mengqi;Zhang, Yutao;Li, Ningyang;Li, Huimin;Zhou, Guihua;Simal-Gandara, Jesus;Li, Ningyang
关键词：
-
Extraction, purification and anticancer activity studies on triterpenes from pomegranate peel
作者：Zhang, Mengqi;Zhang, Yutao;Guo, Xu;Chen, Yingying;Sun, Shutao;Ren, Qidong;Sun, Jinyue;Liu, Chao;Zhang, Mengqi;Zhang, Yutao;Li, Ningyang;Li, Huimin;Zhou, Guihua;Simal-Gandara, Jesus;Li, Ningyang
关键词：
-
Rapid determination of protein, starch and moisture content in wheat flour by near-infrared hyperspectral imaging
作者：Zhang, Jing;Guo, Zhen;Wang, Sihua;Yue, Minghui;Zhang, Shanshan;Yin, Xiang;Ma, Chengye;Ren, Zhishang;Gong, Kuijie
关键词：Hyperspectral imaging; Wheat flour; Near -infrared; Chemical composition; Wavelength selection
