Extraction, purification and anticancer activity studies on triterpenes from pomegranate peel
文献类型： 外文期刊
作者： Zhang, Mengqi 1 ; Zhang, Yutao 1 ; Guo, Xu 1 ; Chen, Yingying 1 ; Li, Huimin 4 ; Zhou, Guihua 4 ; Sun, Shutao 1 ; Ren, Qidong 1 ; Simal-Gandara, Jesus 5 ; Sun, Jinyue 1 ; Li, Ningyang 3 ; Liu, Chao 1 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Novel Food Resources Proc, Minist Agr & Rural Affairs,Key Lab Agroprod Proc, 23788 Gongye North Rd, Jinan 250100, Peoples R China
2.Shandong Huatai Ind Technol Inst Nutr & Hlth Co L, 9 Hongji Rd, Jinan 251400, Peoples R China
3.Shandong Agr Univ, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control Shandong, Tai An 271017, Peoples R China
4.Dev Ctr Melon Fruit & Vegetable Ind Kashi, Kashi 844000, Peoples R China
5.Univ Vigo, Dept Analyt Chem & Food Sci, Nutr & Bromatol Grp, Fac Sci, E-32004 Orense, Spain
6.Ocean Univ China, Coll Food Sci & Engn, Qingdao 266003, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN： 2042-6496
年卷期： 2024 年 15 卷 13 期
页码：
收录情况： SCI
摘要： Pomegranate peel is the by-product of pomegranate processing, which contains a lot of triterpene compounds. In this study, the total triterpenes of pomegranate peel (TPP) were extracted using an ultrasonic-assisted ethanol extraction method under optimal conditions, purified using D-101 macroporous resin to obtain a purity of 75.28%. The triterpenes in TPP were mainly pentacyclic triterpenes determined by LC-MS/MS. Network pharmacological analysis predicted that the anticancer targets were closely related to the MAPK pathway. The in vitro results showed that TPP could inhibit cell proliferation, promote apoptosis, reduce mitochondrial membrane potential and increase ROS levels. The western blot results indicated that the expression levels of the apoptotic proteins Bax, Bcl-2, cytochrome C, cleaved caspase-3 and cleaved caspase-9 were increased. In addition, the protein expression of the MAPK pathway predicted by network pharmacology also changed significantly. These results provided that TPP has potential for adjuvant therapy of tumors.
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