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Companion Animals as Potential Reservoirs of Antibiotic Resistant Diarrheagenic Escherichia coli in Shandong, China

文献类型： 外文期刊

作者： Cui, Lulu 1 ; Zhao, Xiaonan 2 ; Li, Ruibo 1 ; Han, Yu 1 ; Hao, Guijuan 1 ; Wang, Guisheng 3 ; Sun, Shuhong 1 ;

作者机构： 1.Shandong Agr Univ, Coll Anim Sci & Vet Med, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An 271018, Shandong, Peoples R China

2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Peoples R China

3.Shandong Anim Dis Prevent & Control Ctr, Jinan 250100, Peoples R China

关键词： antimicrobial resistance; Escherichia coli; ESBLs; phenotype; companion animals; diarrheagenic

期刊名称：ANTIBIOTICS-BASEL （ 影响因子：5.222； 五年影响因子：5.396 ）

ISSN： 2079-6382

年卷期： 2022 年 11 卷 6 期

页码：

收录情况： SCI

摘要： Antibiotic resistance genes of Escherichia coli (E. coli) from companion animals were still poorly understood. Here, we investigated the extended-spectrum beta-lactamases (ESBLs) resistance genes of E. coli from companion animals in Shandong, China. A total of 79 isolates (80.6%) were recovered from 98 healthy or diarrheal companion animals in 2021, among which ESBLs-producing isolates accounted for 43.0% (34/79), and more than half of ESBL E. coli (ESBL-EC) strains (n = 19) were isolated from healthy companion animals. Diarrheagenic E. coli isolates (45.6%, n = 36) were represented by enterotoxigenic (ETEC) (32.9%), enteropathogenic (EPEC) (10.1%) and enteroinvasive (EIEC) (2.6%), 20 isolates of which were from healthy pets. Among tested antibiotics, resistance to tetracycline (64.6%) was the most commonly observed, followed by doxycycline (59.5%) and ampicillin (53.2%). Notably, all isolates were susceptible to meropenem. The multidrug-resistant (MDR) rate was 49.4%, 20 isolates of which were ESBLs producers; moreover, 23.4%, 16.4% of ESBL-EC strains were resistant to 5 or more, 7 or more antibiotics, respectively. Among the 5 beta-lactamase resistance genes, the most frequent gene was bla(CTX-M) (60.76%), followed by bla(SHV) (40.51%). The plasmid-mediated quinolone resistance (PMQR) gene aac(6')-Ib-cr was detected in 35 isolates. Additionally, ESBL-associated genes (i.e., bla(CTX-M), bla(SHV)) were found in 76.5% ESBL-EC strains, with six isolates carrying bla(CTX-M) and bla(SHV). The marker gene of high-pathogenicity island gene irp2 (encoding iron capture systems) was the most frequency virulence gene. Our results showed that ESBL-EC were widespread in healthy or diarrhea companion animals, especially healthy pets, which may be a potential reservoir of antibiotic resistance, therefore, enhancing a risk to public and animal health.

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