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Concentrated fish oil ameliorates non-alcoholic fatty liver disease by regulating fibroblast growth factor 21-adiponectin axis

文献类型： 外文期刊

作者： Guo, Xiao-Fei 1 ; Wang, Chong 1 ; Yang, Ting 1 ; Ma, Wen-Jun 1 ; Zhai, Jie 3 ; Zhao, Ting 4 ; Xu, Tong-Cheng 5 ; Li, Jun 6 ; Liu, He 6 ; Sinclair, Andrew J. 7 ; Li, Duo 1 ;

作者机构： 1.Qingdao Univ, Inst Nutr & Hlth, Qingdao, Peoples R China

2.Qingdao Univ, Sch Publ Hlth, Qingdao, Peoples R China

3.Qingdao Univ, Songshan Hosp, Qingdao, Peoples R China

4.Qingdao Univ, Affiliated Hosp, Qingdao, Peoples R China

5.Shandong Acad Agr Sci, Jinan, Peoples R China

6.Bohai Univ, Coll Food Sci & Technol, Jinzhou, Peoples R China

7.Monash Univ, Dept Nutr Dietet & Food, Notting Hill, Vic, Australia

8.Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou, Peoples R China

关键词： Fish oil; Non-alcoholic fatty liver disease; Fibroblast growth factor 21; Adiponectin

期刊名称：NUTRITION （ 影响因子：4.893； 五年影响因子：4.973 ）

ISSN： 0899-9007

年卷期： 2022 年 99-100 卷

页码：

收录情况： SCI

摘要： Objectives: The fibroblast growth factor 21 (FGF21)-adiponectin axis participates in energy hemostasis and obesity-related syndrome. The present study aimed to investigate whether concentrated fish oil (FO) intervention could alleviate non-alcoholic fatty liver disease (NAFLD) via the regulation of the FGF21-adiponectin axis. Methods: In a randomized controlled trial, 61 patients with NAFLD, age 55.9 ?? 15.6 y, were randomly divided into two groups: FO (3 g/d; n = 30) and corn oil (CO; 3 g/d; n = 31), which served as the control group. Results: After a 3-mo intervention, there were significant net reductions in serum alanine transaminase (-5.4 ?? 14.5 U/L vs. -0.25 ?? 4.70 U/L; P = 0.001) and triacylglycerol (-0.70 ?? 1.10 mmol/L vs. 0.11 ?? 1.04 mmol/L; P = 0.018) levels in the FO group compared with the CO group. Furthermore, the mean changes of FGF21 levels (-16.3 ?? 20.1 pg/mL vs. 7.2 ?? 32.9 pg/mL; P = 0.002) were significantly decreased, but adiponectin levels (1.14 ?? 1.53 mg/mL vs. -0.42 ?? 2.04 pg/mL; P = 0.011) were significantly increased in the FO group compared with the CO group. In the animal study, the mice fed the high-fat diet demonstrated characteristics of NAFLD. The administration of FO significantly improved high-fat diet-induced hepatic steatosis, insulin resistance, and inflammation compared with the high-fat control group. In addition, FO improved the sensitivity of FGF21, and stimulated the expression levels of adiponectin in the liver. Conclusions: The present study suggested that FO could potentially ameliorate NAFLD through mediating the FGF21-adiponectin axis.

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