文献类型： 外文期刊
作者： Ma, Yingru 1 ; Zheng, Limei 1 ; Li, Chen 2 ; Wu, Xiaoyan 2 ; Shi, Jianli 2 ; Liu, Chang 2 ; Han, Hong 2 ; Xu, Shaojian 2 ; Hrabchenko, Nataliia 2 ; Huang, Mengjie 3 ; Qiu, Jianhua 3 ; Li, Jun 1 ; Han, Xianjie 1 ;
作者机构： 1.Qingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
2.Shandong Acad Agr Sci, Shandong Prov Key Lab Anim Dis Control & Breeding, Inst Anim Sci & Vet Med, Jinan, Peoples R China
3.Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An, Peoples R China
关键词： senecavirus A; pigs; virus isolation; IFA; evolutionary analysis; Western blotting
期刊名称：VETERINARSKI ARHIV （ 影响因子：0.5； 五年影响因子：0.6 ）
ISSN： 0372-5480
年卷期： 2023 年 93 卷 2 期
页码：
收录情况： SCI
摘要： Senecavirus A (SVA), previously called the Seneca Valley virus, is the only member of the genus Senecavirus within the family Picornaviridae. This virus was discovered as a serendipitous finding in 2002 and named Seneca Valley virus 001 (SVV-001). SVA is an emerging pathogen that can cause vesicular lesions and epidemic transient neonatal a sharp decline in swine. In this study, an SVA strain was isolated from a pig herd in Shandong Province in China and identified as SVA-CH-SDFX-2022. The full-length genome was 7282 nucleotides (nt) in length and contained a single open reading frame (ORF), excluding the poly (A) tails of the SVA isolates. Phylogenetic analysis showed that the isolate shares its genomic organization, resembling and sharing high nucleotide identities of 90.5% to 99.6%, with other previously reported SVA isolates. The strain was proved by in vitro characterization and the results demonstrate that the virus has robust growth ability in vitro. The recombination event of the SVA-CH-SDFX-2022 isolate was found and occurred between nts 1836 and 2710, which included the region of the VP2 (partial), and VP3 (partial) genes. It shows the importance of faster vaccine development and a better understanding of virus infection and spread because of increased infection rates and huge economic losses. This novel incursion has substantial implications for the regional control of vesicular transboundary diseases, and will be available for further study of the epidemiology of porcine SVA. Our findings provide useful data for studying SVA in pigs.
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