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New Tetramic Acids Comprising of Decalin and Pyridones From Chaetomium olivaceum SD-80A With Antimicrobial Activity

文献类型： 外文期刊

作者： Wang, Xinzhu 1 ; Zhao, Liya 2 ; Liu, Chao 3 ; Qi, Jun 2 ; Zhao, Peipei 2 ; Liu, Zhaoming 4 ; Li, Chunlei 2 ; Hu, Yingying 1 ; Yin, Xin 2 ; Liu, Xin 2 ; Liao, Zhixin 1 ; Zhang, Lixin 2 ; Xia, Xuekui 2 ;

作者机构： 1.Southeast Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Nanjing, Peoples R China

2.Qilu Univ Technol, Biol Inst, Shandong Prov Key Lab Biosensor, Shandong Acad Sci, Jinan, Peoples R China

3.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan, Peoples R China

4.Guangdong Acad Sci, Guangdong Inst Microbiol, Guangzhou, Peoples R China

5.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China

关键词： Chaetomium olivaceum; tetramic acids; isolation; anti-MRSA; biosynthesis pathway

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2020 年 10 卷

页码：

收录情况： SCI

摘要： Cycloaddition reactions such as intramolecular Diels-Alder (IMDA) are extremely important in constructing multicyclic scaffolds with diverse bioactivities. Using MycB as a biomarker, three new polyketides - Chaetolivacines A (1), B (3), and C (4) - with one known compound Myceliothermophin E (2) comprising of decalin and 4-hydroxy-2-pyridones were obtained from the culture of Chaetomium olivaceum SD-80A under the guidance of gene mining. The structures of these compounds were established using detailed 1D, 2D NMR, and high-resolution electron spray ionization mass spectroscopy (HRESIMS) analysis. The relative and absolute configurations of the compounds 1, 3, and 4 were elucidated by NOESY and ECD. The biosynthesis pathways of these compounds were proposed, which involves in three key genes ChaA [polyketide synthase-non-ribosomal peptide synthetases (PKS-NRPS)], ChaB, and ChaC. Compounds 1-4 were tested for their antimicrobial activities, and compounds 2 and 3 showed moderate bioactivity against Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) with MIC values of 15.8 and 27.1 mu M. The results showed that configuration of C-21 in 3 and 4 is important for anti-SA and anti-MRSA activities. This study reveals the significant potential of the genus Chaetomium in producing new PKS-NRPS, therefore increasing the speed in the mining for new sources of antimicrobial agents.

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[1]New Tetramic Acids Comprising of Decalin and Pyridones From Chaetomium olivaceum SD-80A With Antimicrobial Activity. Wang, Xinzhu,Hu, Yingying,Liao, Zhixin,Zhao, Liya,Qi, Jun,Zhao, Peipei,Li, Chunlei,Yin, Xin,Liu, Xin,Zhang, Lixin,Xia, Xuekui,Liu, Chao,Liu, Zhaoming,Zhang, Lixin. 2020

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