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Depletion of florfenicol and florfenicol amine in eggs of laying hens and growing pullets after oral administration

文献类型： 外文期刊

作者： Li, Xia 1 ; Chen, Lu 1 ; Yue, Hui 1 ; Feng, Hua 1 ; Xu, Enmin 2 ; Wei, Xiuli 2 ; Han, Xiaoli 3 ; Deng, Ligang 1 ; Li, Zengme 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Agr Qual Stand & Testing Technol Res, Jinan 250100, Shandong, Peoples R China

2.Shandong Vet Drug Qual Inspect Inst, Jinan, Shandong, Peoples R China

3.Acad Modern Ecol Agr Ind Technol, Tai An, Shandong, Peoples R China

关键词： Florfenicol; flofenicol amine; growing pullets; laying hens; ultrahigh-performance liquid chromatography-tandem mass spectrometry

期刊名称：FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT （ 影响因子：3.057； 五年影响因子：2.96 ）

ISSN： 1944-0049

年卷期： 2020 年 37 卷 9 期

页码：

收录情况： SCI

摘要： In this study, we carried out two experiments to evaluate depletion of florfenicol (FF) and its metabolite florfenicol amine (FFA) in eggs from growing pullets and laying hens. Eggs were collected, and the egg white and yolk were separated. FF and FFA were analysed by liquid chromatography-tandem mass spectrometry. In the first experiment, 30 laying hens were given FF capsules at 50 mg/kg center dot bw(-1)daily for 5 d. FF + FFA was detectable in egg white (1,190 mu g/kg) on day 1 of treatment and increased slowly thereafter. After treatment, the residues decreased rapidly and were not detected by day 11. In yolk, residues were detected at a lower concentration on day 1 and increased dramatically to 3308 mu g/kg at the end of treatment. The residues remained steady over the next 4 days post-treatment, followed by a rapid drop. Residues were not detectable on day 15 post-treatment. In the second experiment, four groups (B1 through B4) of growing pullets were treated in the same manner for 25, 20, 15, and 10 days before egg primiparity. FF and FFA were not detectable in the eggs of group B1; however, they were detectable in egg whites and yolks of groups B2, B3, and B4. The highest total concentrations of FF and FFA detected in egg white and yolk of group B4 were 3,190 mu g/kg and 3,214 mu g/kg, respectively. Thereafter, concentrations decreased until no more residues were detected in egg whites or yolks on days 17 and 21 post-treatment, respectively. Therefore, drug treatment should be stopped at least 21 d before primiparity of growing pullets to guarantee food safety.

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