Production of a matrix certified reference material for measurement and risk monitoring of clenbuterol in mutton
文献类型： 外文期刊
作者： Li, FuKai 1 ; Zhou, Jian 1 ; Wang, Min 1 ; Zhang, LiYuan 1 ; Yang, MengRui 1 ; Deng, LiGang 2 ;
作者机构： 1.Chinese Acad Agr Sci CAAS, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China
2.Shandong Acad Agr Sci, Inst Agr Qual Stand & Testing Technol Res, Jinan 250100, Peoples R China
关键词： Matrix certified reference material; Clenbuterol; Agonist; Homogeneity and stability; Uncertainty
期刊名称：ANALYTICAL AND BIOANALYTICAL CHEMISTRY （ 影响因子：4.3； 五年影响因子：4.0 ）
ISSN： 1618-2642
年卷期： 2023 年 415 卷 8 期
页码：
收录情况： SCI
摘要： A novel matrix certified reference material (CRM) for clenbuterol in mutton (GBW 10216) was developed to assist measurement and risk monitoring of clenbuterol in mutton. The candidate CRM raw samples were obtained by oral administration of clenbuterol and investigating the pharmacokinetics of clenbuterol in sheep. A high-precision isotope dilution coupled with liquid chromatography tandem mass spectrometry (LC-ID-MS/MS) method was established and assigned the value of clenbuterol in mutton powder through combined detection of nine inter-laboratories. The certified value with expanded uncertainty was 21.1 +/- 2.2 mu g/kg (k = 2, 95% confidence) for clenbuterol in mutton. The prepared matrix CRM was sufficiently homogeneous between and within bottles. The long-term stability of clenbuterol in mutton powder was evaluated for 12 months at -20? and short-term stability for 7 days at 4? and 50?. The uncertainties originating from characterization, homogeneity, and stability were systematically analyzed and evaluated. The prepared matrix CRM can be applied for proficiency testing and nationwide risk monitoring programs to guarantee the accuracy and comparability of clenbuterol measurement results in mutton.
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