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Effects of in ovo feeding of t10,c12-conjugated linoleic acid on hepatic lipid metabolism and subcutaneous adipose tissue deposition in newly hatched broiler chicks

文献类型： 外文期刊

作者： Xu, Wentao 1 ; Song, Zhigang 2 ; Wang, Wenbin 1 ; Li, Xia 1 ; Yan, Peipei 1 ; Shi, Tianhong 1 ; Fu, Chunyan 1 ; Liu, Xuelan 1 ;

作者机构： 1.Shandong Acad Agr Sci, Poultry Inst, Jinan 250023, Peoples R China

2.Shandong Agr Univ, Dept Anim Sci, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An 271018, Shandong, Peoples R China

3.Shandong Prov Key Lab Poultry Dis Diag & Immunol, Jinan 250023, Peoples R China

4.Poultry Breeding Engn Technol Ctr Shandong Prov, Jinan 250023, Peoples R China

关键词： t10,c12-conjugated linoleic acid; in ovo feeding; liver; lipid metabolism; newly hatched chicks

期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）

ISSN：

年卷期： 2022 年 101 卷 5 期

页码：

收录情况： SCI

摘要： The purpose of this study was to investigate whether in ovo feeding of t10,c12-conjugated linoleic acid (CLA) could regulate hepatic lipid metabolism and decrease lipid accumulation in newly hatched chicks. Three hundred and sixty fertilely specific pathogen-free hatching eggs were selected and randomly divided into 6 groups. On embryonic day 11 of incubation (E11), 0, 1.5, 3.0, 4.5, 6.0, or 7.5 mg t10,c12-CLA were injected into the eggs. The results indicated that in ovo feeding of t10,c12-CLA significantly decreased the subcutaneous adipose tissue (SAT) mass and the relative SAT weight of newly hatched chicks in linear and quadratic manners (P < 0.05). In liver, the levels of triglycerides were reduced linearly and quadratically and total cholesterol were reduced quadratically as the dose of t10,c12-CLA increased (P < 0.05). Meanwhile, the hepatic carnitine palmitoyltransferase-1a (CPT1a) content and polyunsaturated fatty acid proportion were increased quadratically in t10,c12-CLA groups (P < 0.05), accompanied by the decrease of malondialdehyde level and the increase of glutathione peroxidase and total antioxidant capacity activities (P < 0.05). In addition, in ovo feeding of t10,c12-CLA decreased the mRNA expression levels of fatty acid synthase, acetylCoA carboxylase 1 in linear and quadratic manners (P < 0.05), and decreased the mRNA expression of adipose triacylglyceride lipase and stearoyl-CoA desaturase significantly in liver (P < 0.05), accompanied by upregulating the mRNA expression of CPT1a quadratically and AMP-activated protein kinase alpha linearly and quadratically (P < 0.05). In SAT, the mRNA expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and sterol regulatory element-binding protein-1c were decreased linearly and quadratically (P < 0.05), and the expression of PPAR alpha and CPT1a genes were increased linearly and quadratically as the dose of t10,c12-CLA increased (P < 0.05). In conclusion, our findings demonstrate that in ovo feeding of t10,c12-CLA alleviates lipid accumulation in newly hatched chicks by suppressing fatty acid synthesis and stimulating lipolysis in the liver and inhibiting adipocyte differentiation in subcutaneous adipose tissue.

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