文献类型： 外文期刊
作者： Liu, J. 1 ; Nong, Q. 1 ; Wang, J. 2 ; Chen, W. 1 ; Xu, Z. 1 ; You, W. 1 ; Xie, J. 3 ; Wang, Y. 1 ; Shan, T. 1 ;
作者机构： 1.Zhejiang Univ, Coll Anim Sci, Zhejiang Prov Lab Feed & Anim Nutr, Key Lab Mol Anim Nutr,Minist Educ,Inst Feed Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China
2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Prov Key Lab Anim Dis Control & Breeding, Jinan 250100, Peoples R China
3.Shandong Chunteng Food Co Ltd, Zaozhuang 277500, Shandong, Peoples R China
关键词： CRTCs; DLY pig; Heigai pig; intramuscular fat; meat quality; muscle fiber type
期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）
ISSN： 0268-9146
年卷期： 2020 年 51 卷 4 期
页码：
收录情况： SCI
摘要： The cAMP responsive element binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) is a member of the CRTC protein family and plays an important role in energy metabolism. The aim of this study was to determine if the expression of porcine CRTC3 is related to intramuscular fat (IMF) deposition and meat quality in Heigai pigs (a local fatty breed in China) and Duroc x Landrace x Yorkshire (DLY) pigs (a lean crossbred pig widely cultured in China). In addition, the effect of ectopic expression of CRTC3 on gene expression in porcine IMF adipocytes was also examined. Our results showed that Heigai pigs had lower lean percentage, thicker back fat thickness and smaller loin muscle area than DLY pigs. Compared with DLY pigs, Heigai pigs had higher marbling scores, better meat color and higher IMF contents and triglyceride concentrations. Higher levels of oxidative metabolic enzyme and expression of the slow oxidative muscle fiber-related genes were observed in longissimus dorsi muscle and psoas major muscle (P < 0.05) from Heigai pigs. Notably, CRTC3 and adipocyte-specific marker genes were highly expressed in muscle tissues of Heigai pigs. The expression of lipolysis-related genes ATGL and HSL were lower in Heigai muscles. Moreover, forced expression of CRTC3 promoted lipid accumulation and increased the expression of PPAR gamma, C/EBP alpha, leptin and FABP4 (P < 0.05), whereas it decreased the expression of ATGL and HSL in IMF adipocytes. These results suggest that CRTC3 expression is associated with lipid accumulation and IMF deposition in pigs.
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