Genome- Wide Association Study of Abdominal Fat in Wenshang Barred Chicken Based on the Slaf- Seq Technology
文献类型： 外文期刊
作者： Liu, W. 1 ; Liu, J. 1 ; Zhou, Y. 1 ; Cao, D. 1 ; Lei, Q. 1 ; Han, H. 1 ; Wang, J. 1 ; Li, D. 1 ; Gao, J. 1 ; Li, H. 1 ; Li, F. 1 ;
作者机构： 1.Shandong Acad Agr Sci, Poultry Inst, Jinan 250100, Shandong, Peoples R China
2.Poultry Breeding Engn Technol Ctr Shandong Prov, Jinan 250100, Shandong, Peoples R China
关键词： Abdominal fat traits; genome-wide association study; SLAF-seq; Wenshang Barred chicken
期刊名称：BRAZILIAN JOURNAL OF POULTRY SCIENCE （ 影响因子：1.019； 五年影响因子：1.492 ）
ISSN： 1516-635X
年卷期： 2022 年 24 卷 4 期
页码：
收录情况： SCI
摘要： Chicken abdominal fat (AF) is an economically important trait, and many studies have been conducted on genetic selection for AF. However, previous studies have focused on detecting functional chromosome mutations or regions using gene chips. The present study used the specific-locus amplified fragment sequencing (SLAF- seq) technology to perform a genome-wide association study (GWAS) on purebred Wengshang Barred chicken. A total of 1,286,715 single- nucleotide polymorphisms (SNPs) were detected, and 175,211 SNPs were selected as candidate SNPs for genomewide association analysis using TASSEL general linear models. Two SNPs markers reached genome-wide significance. Of these, rs7943847, rs127627362 were significantly associated with AF at 120 days. These SNPs are close to eight genes (SLC16A6, ARSG, WIPI1, PRKAR1A, FAM20A, ABCA8, ABCA9, CPQ,). These results would enrich the studies on AF and promote the use of Chinese chicken, especially the Wenshang Barred chicken.
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