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Fermented and Germinated Processing Improved the Protective Effects of Foxtail Millet Whole Grain Against Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis and Gut Microbiota Dysbiosis in C57BL/6 Mice

文献类型： 外文期刊

作者： Zhang, Yuhan 1 ; Liu, Wei 2 ; Zhang, Di 3 ; Yang, Yanbing 2 ; Wang, Xianshu 2 ; Li, Lingfei 1 ;

作者机构： 1.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming, Yunnan, Peoples R China

2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan, Peoples R China

3.Shandong Univ, Qilu Hosp, Jinan, Peoples R China

关键词： foxtail millet; fermentation; germination; gut microbiota; inflammatory bowel disease; mouse colitis model

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.576； ）

ISSN： 2296-861X

年卷期： 2021 年 8 卷

页码：

收录情况： SCI

摘要： This study investigated the effects of foxtail millet whole grain flours obtained through different processing methods on alleviating symptoms and gut microbiota dysbiosis in a dextran sulfate sodium (DSS)-induced murine colitis model. Sixty C57BL/6 mice were divided into six groups (n = 10 in each group), including one control group (CTRL) without DSS treatment and five DSS-treated groups receiving one of the following diets: AIN-93M standard diet (93MD), whole grain foxtail millet flour (FM), fermented (F-FM), germinated (G-FM), and fermented-germinated foxtail millet flour (FG-FM). A comparison of the disease activity index (DAI) demonstrated that foxtail millet whole grain-based diets could alleviate the symptoms of enteritis to varying degrees. In addition, 16S rRNA gene sequencing revealed that FG-FM almost completely alleviated DSS-induced dysbiosis. Mice on the FG-FM diet also had the lowest plasma IL-6 levels and claudin2 expression levels in the colon, indicating reduced systemic inflammation and improved gut barrier function. This study suggested that foxtail millet whole grain is an attractive choice for the intervention of IBD and gut microbiota dysbiosis, and its prebiotic properties are highly affected by the processing methods.

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[1]Fermented and Germinated Processing Improved the Protective Effects of Foxtail Millet Whole Grain Against Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis and Gut Microbiota Dysbiosis in C57BL/6 Mice. Zhang, Yuhan,Li, Lingfei,Zhang, Yuhan,Liu, Wei,Yang, Yanbing,Wang, Xianshu,Zhang, Yuhan,Zhang, Di. 2021

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