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Elucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses

文献类型： 外文期刊

作者： Wang, Jie 1 ; Liu, Jie 1 ; Lei, Qiuxia 1 ; Liu, Zhihe 4 ; Han, Haixia 1 ; Zhang, Shuer 3 ; Qi, Chao 3 ; Liu, Wei 1 ; Li, Dapeng 1 ; Li, Fuwei 1 ; Cao, Dingguo 1 ; Zhou, Yan 1 ;

作者机构： 1.Shandong Acad Agr Sci, Poultry Inst, Poultry Breeding Engn Technol Ctr Shandong Prov, Jinan 250023, Shandong, Peoples R China

2.Jinan Key Lab Poultry Germplasm Resources Innovat, Jinan 250023, Shandong, Peoples R China

3.Shandong Anim Husb Gen Stn, Jinan 250023, Peoples R China

4.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China

关键词： Chicken; GWAS; Body weight; Body size

期刊名称：BMC GENOMICS （ 影响因子：4.4； 五年影响因子：4.7 ）

ISSN： 1471-2164

年卷期： 2024 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Background Body weight and size are important economic traits in chickens. While many growth-related quantitative trait loci (QTLs) and candidate genes have been identified, further research is needed to confirm and characterize these findings. In this study, we investigate genetic and genomic markers associated with chicken body weight and size. This study provides new insights into potential markers for genomic selection and breeding strategies to improve meat production in chickens.Methods We performed whole-genome resequencing of and Wenshang Barred (WB) chickens (n = 596) and three additional breeds with varying body sizes (Recessive White (RW), WB, and Luxi Mini (LM) chickens; (n = 50)). We then used selective sweeps of mutations coupled with genome-wide association study (GWAS) to identify genomic markers associated with body weight and size.Results We identified over 9.4 million high-quality single nucleotide polymorphisms (SNPs) among three chicken breeds/lines. Among these breeds, 287 protein-coding genes exhibited positive selection in the RW and WB populations, while 241 protein-coding genes showed positive selection in the LM and WB populations. Genomic heritability estimates were calculated for 26 body weight and size traits, including body weight, chest breadth, chest depth, thoracic horn, body oblique length, keel length, pelvic width, shank length, and shank circumference in the WB breed. The estimates ranged from 0.04 to 0.67. Our analysis also identified a total of 2,522 genome-wide significant SNPs, with 2,474 SNPs clustered around two genomic regions. The first region, located on chromosome 4 (7.41-7.64 Mb), was linked to body weight after ten weeks and body size traits. LCORL, LDB2, and PPARGC1A were identified as candidate genes in this region. The other region, located on chromosome 1 (170.46-171.53 Mb), was associated with body weight from four to eighteen weeks and body size traits. This region contained CAB39L and WDFY2 as candidate genes. Notably, LCORL, LDB2, and PPARGC1A showed highly selective signatures among the three breeds of chicken with varying body sizes.Conclusion Overall this study provides a comprehensive map of genomic variants associated with body weight and size in chickens. We propose two genomic regions, one on chromosome 1 and the other on chromosome 4, that could helpful for developing genome selection breeding strategies to enhance meat yield in chickens.

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