文献类型： 外文期刊
作者： Liu, Chao 1 ; Liao, Zhi-Xin 1 ; Liu, Shi-Jun 1 ; Sun, Jin-Yue 2 ; Yao, Gui-Yang 3 ; Wang, Heng-Shan 3 ;
作者机构： 1.Southeast Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
3.Guangxi Normal Univ, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China
关键词： Rubus phoenicolasius; Rosaceae; pregnane glycoside; antiproliferative
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期： 2014 年 28 卷 21 期
页码：
收录情况： SCI
摘要： Chemical investigations of the whole plant ethanol extract of Rubus phoenicolasius led to the isolation and identification of a new pregnane glycoside, 3-O-beta-glucopyranosyl-3 beta, 15 beta-dihydroxypregn-5-en-20-one (1), along with other nine known compounds (2-10). All the isolates were reported from this plant for the first time. The structure of compound 1 was determined by detailed analysis of its spectral data including 1D and 2D NMR. In vitro anti-proliferative activities of compounds 1-3 on MCF-7 and NCI-H460 tumour cell lines were evaluated, and compound 1 was active against the two cell lines with IC50 values of 15.6 and 13.5 mu M, respectively.
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