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Intestine-targeted delivery potency of the O-carboxymethyl chitosangum Arabic coacervate: Effects of coacervation acidity and possible mechanism

文献类型： 外文期刊

作者： Huang, Guo-Qing 1 ; Liu, Li-Na 2 ; Han, Xiao-Na 1 ; Xiao, Jun-Xia 1 ;

作者机构： 1.Qingdao Agr Univ, Coll Food Sci & Engn, Qingdao 266109, Peoples R China

2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China

关键词： O-carboxymethyl chitosan;Gum Arabic;Coacervate;Intestine-targeted delivery;Microstructure

期刊名称：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS （ 影响因子：7.328； 五年影响因子：6.654 ）

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收录情况： SCI

摘要： The potential of the glutaraldehyde-crosslinked O-carboxymethyl chitosan (O-CMC)-gum Arabic (GA) coacervate as an intestine-targeted delivery system for hydrophobic compounds was concerned. OCMC-GA coacervates and emulsified bovine serum albumin (BSA)-loaded microcapsules were prepared in pH 3.0, 4.5, and 6.0 and their swelling behaviors as well as BSA release profiles in simulated gastrointestinal fluids were measured. All the coacervates showed higher swelling ratios in the simulated gastric solution than in the simulated intestine and colon solutions and the values increased as the coacervation pH increased from 3.0 to 6.0, but a reversed trend was observed for the BSA release profile. SEM, TEM, and CLSM analysis revealed that the coacervation acidity influenced the swelling and BSA release behavior by changing the matrix density and O-CMC content of the coacervates. It was concluded that the O-CMC-GA coacervate could be used to deliver hydrophobic compounds to the intestine and its delivery performance could be tailored by selecting appropriate coacervation acidity and crosslinking degree. (C) 2017 Elsevier B.V. All rights reserved.

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