Complex coacervation of carboxymethyl konjac glucomannan and chitosan and coacervate characterization
文献类型： 外文期刊
作者： Xiao, Jun-Xia 1 ; Wang, Lu-Hui 1 ; Xu, Tong-Cheng 2 ; Huang, Guo-Qing 1 ;
作者机构： 1.Qingdao Agr Univ, Coll Food Sci & Engn, Qingdao 266109, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Shandong, Peoples R China
关键词： Carboxymethyl konjac glucomannan; Chitosan; Complex coacervation; Degree of substitution; Colon-targeted delivery
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2019 年 123 卷
页码：
收录情况： SCI
摘要： Carboxymethyl konjac glucomannan (CMKGM) shows potential in the construction of colon-targeted delivery systems through electrostatic interaction-based techniques. Its coacervation with chitosan (CHI) was investigated as a function of degree of substitution (DS). CMKGMs displayed the same optimum coacervation conditions of pH 6.5 and mass ratio 1:1 with CHI, but the coacervate yield was positively related to their DS. The coacervation was weakened by the presence of NaCI, but was not affected in temperatures 25-75 degrees C and total biopolymer concentrations 0.05-0.15% (w/v). Both electrostatic interaction and hydrogen bonding were involved in the coacervation and a higher DS contributed a denser network structure, a smaller particle size, and greater elasticity. The coacervates maintained their structures in simulated gastrointestinal fluids, but could be degraded by the beta-mannanase in simulated colonic fluid. Hence, CMKGMs could be used in colon-targeted and enzyme-triggered delivery systems and the delivery performance could be tailored by varying their DS. (C) 2018 Elsevier B.V. All rights reserved.
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