Discovery of a series of novel compounds with moderate anti-avian H5N1 influenza virus activity in chick embryo
文献类型： 外文期刊
作者： Xie, Yuanchao 1 ; Huang, Bing 2 ; Yu, Kexiang 2 ; Shi, Fangyuan 1 ; Xu, Wenfang 1 ;
作者机构： 1.Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Shandong, Peoples R China
2.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250023, Shandong, Peoples R China
关键词： Influenza;Neuraminidase;Flavonoid;Amino acid
期刊名称：MEDICINAL CHEMISTRY RESEARCH （ 影响因子：1.965； 五年影响因子：1.98 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Enlightened by some flavonoid compounds, which had been found as influenza neuraminidase inhibitors, we designed and synthesized a series of novel compounds containing different amino acid fragments. We also reported a simple synthetic route from oseltamivir to prepare its active form which was used as the positive control. The result of enzyme inhibition assay indicated that all the designed compounds displayed weak inhibitory activity against neuraminidase. However, they showed moderate anti-avian H5N1 influenza virus activity in chick embryo. Besides interfering with the function of neuraminidase, these compounds seemed to inhibit the replication of influenza virus by some other mechanism which deserved deep study.
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