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Preparation and evaluation of the immune efficacy of an inactivated fowl adenovirus 8a serotype oil emulsion vaccine

文献类型： 外文期刊

作者： Wu, Jingqi 2 ; Lu, Xiao 2 ; Song, Lingling 2 ; Liu, Liping 2 ; Gao, Yuehua 2 ; Li, Hongmei 3 ; Yu, Kexiang 2 ; Qi, Lihong 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Peoples R China

2.Shandong Acad Agr Sci, Poultry Inst, Shandong Prov Key Lab Poultry Dis Diag & Immunol, Jinan, Peoples R China

3.Shandong Agr Univ, Shandong Prov Key Lab Anim Biotechnol & Dis Contro, Tai An 271018, Peoples R China

4.Shandong Agr Univ, Coll Vet Med, Tai An 271018, Peoples R China

5.Shandong Agr Univ, Shandong Prov Engn Technol Res Ctr Anim Dis Contro, Tai An 271018, Peoples R China

关键词： Fowl adenovirus; FAdV-8a; Inclusion body hepatitis; Oil emulsion inactivated vaccine

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2024 年 10 卷 5 期

页码：

收录情况： SCI

摘要： In recent years, fowl adenovirus (FAdV) transmission has significantly increased worldwide, leading to substantial economic losses in the poultry industry. The virus causes hepatitishydropericardium syndrome (HHS) and inclusion body hepatitis (IBH). The prevalent FAdV strains in China are FAdV-4, FAdV-8a, FAdV-8b, and FAdV-11. Vaccines for FAdV-4 and FAdV-8b, which prevent HHS and IBH, are available commercially, but no vaccine exists for FAdV-8a. To address this issue, we developed a vaccine using an oil emulsion to inactivate the FAdV-8a serotype. Additionally, we built a fluorescence quantitative PCR for the detection of the virus. The lowest concentration detected was 4.11 x 101 copies/mu L. The study's results illustrated that the FAdV-8a oil emulsion vaccine effectively produced significant antibodies and offered ample protection for poultry. This vaccine can potentially limit the transmission of IBH resulting from FAdV-8a in China.

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