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The Emergence of Viral Encephalitis in Donkeys by Equid Herpesvirus 8 in China

文献类型： 外文期刊

作者： Wang, Tongtong 1 ; Hu, Leyu 2 ; Liu, Mengyuan 1 ; Wang, Tianjiao 1 ; Hu, Xinyao 1 ; Li, Ying 1 ; Liu, Wenqiang 1 ; Li, Yubao 1 ; Wang, Yonghui 1 ; Ren, Huiying 2 ; Zhang, Wei 3 ; Wang, Changfa 1 ; Li, Liangliang 1 ;

作者机构： 1.Liaocheng Univ, Res Inst Donkey High Efficiency Breeding & Ecol F, Coll Agron, Liaocheng, Peoples R China

2.Qingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China

3.Shandong Acad Agr Sci, Dairy Cattle Res Ctr, Jinan, Peoples R China

关键词： EHV-8; donkey; neurological diseases; pathogenicity; mice

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN：

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： The equine herpesvirus type 8 (EHV-8) can cause significant economic losses in the global horses and donkey industry. The disease has been associated with abortion and respiratory symptoms. However, it is rare for a study to be reported about donkeys with neurological diseases induced by EHV-8 infection. In the present study, one 2-year-old male donkey, from a large-scale donkey farm in China, died with a severe neurological disorder. The causative agent, donkey/Shandong/10/2021 (GenBank accession: ), was identified and isolated from the brain tissue of the dead donkey. Meanwhile, BALB/c mice were used as an animal model to evaluate the pathogenicity of the EHV-8 isolate. Our data showed that EHV-8 was positive in brains by PCR and immunohistochemistry, which induced typical viral encephalitis lesions in both donkey and mice consistent with clinical signs. For the first time, we reported that EHV-8 had been isolated from donkeys with a neurological illness in China, which is helpful to reveal the pathogenicity of EHV-8 in the donkey.

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[1]The Emergence of Viral Encephalitis in Donkeys by Equid Herpesvirus 8 in China. Wang, Tongtong,Liu, Mengyuan,Wang, Tianjiao,Hu, Xinyao,Li, Ying,Liu, Wenqiang,Li, Yubao,Wang, Yonghui,Wang, Changfa,Li, Liangliang,Hu, Leyu,Ren, Huiying,Zhang, Wei. 2022

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