您好，欢迎访问山东省农业科学院文献资源数据库平台

Swine Influenza H1N1 Virus Induces Acute Inflammatory Immune Responses in Pig Lungs: a Potential Animal Model for Human H1N1 Influenza Virus

文献类型： 外文期刊

作者： Khatri, Mahesh 1 ; Dwivedi, Varun 1 ; Krakowka, Steven 2 ; Manickam, Cordelia 1 ; Ali, Ahmed 1 ; Wang, Leyi 1 ; Qin, Z 1 ;

作者机构： 1.Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA

2.Ohio State Univ, Coll Vet Med, Dept Vet Biosci, Columbus, OH 43210 USA

3.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250023, Peoples R China

4.Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 43210 USA

5.Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 4

关键词： IFN-gamma: interferon-gamma;IgA antibody: immunoglobulin A antibody;Th1 cytokine: proinflammatory;Th2 cytokine: proinflammatory;Th3 cytokine: proinflammatory nasal secretion

期刊名称：JOURNAL OF VIROLOGY （ 影响因子：5.103； 五年影响因子：5.078 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Pigs are capable of generating reassortant influenza viruses of pandemic potential, as both the avian and mammalian influenza viruses can infect pig epithelial cells in the respiratory tract. The source of the current influenza pandemic is H1N1 influenza A virus, possibly of swine origin. This study was conducted to understand better the pathogenesis of H1N1 influenza virus and associated host mucosal immune responses during acute infection in humans. Therefore, we chose a H1N1 swine influenza virus, Sw/OH/24366/07 (SwIV), which has a history of transmission to humans. Clinically, inoculated pigs had nasal discharge and fever and shed virus through nasal secretions. Like pandemic H1N1, SwIV also replicated extensively in both the upper and lower respiratory tracts, and lung lesions were typical of H1N1 infection. We detected innate, proinflammatory, Th1, Th2, and Th3 cytokines, as well as SwIV-specific IgA antibody in lungs of the virus-inoculated pigs. Production of IFN-gamma by lymphocytes of the tracheobronchial lymph nodes was also detected. Higher frequencies of cytotoxic T lymphocytes, gamma delta T cells, dendritic cells, activated T cells, and CD4(+) and CD8(+) T cells were detected in SwIV-infected pig lungs. Concomitantly, higher frequencies of the immunosuppressive T regulatory cells were also detected in the virus-infected pig lungs. The findings of this study have relevance to pathogenesis of the pandemic H1N1 influenza virus in humans; thus, pigs may serve as a useful animal model to design and test effective mucosal vaccines and therapeutics against influenza virus.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台