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Molecular characterization and pathogenicity study of a highly pathogenic strain of chicken anemia virus that emerged in China

文献类型： 外文期刊

作者： Fang, Lichun 1 ; Jia, Huiyue 2 ; Hu, Yuhang 3 ; Wang, Yixin 2 ; Cui, Zhizhong 2 ; Qi, Lihong 1 ; Zhao, Peng 2 ;

作者机构： 1.Shandong Acad Agr Sci, Innovat Team Major Livestock & Poultry Dis Prevent, Jinan, Shandong, Peoples R China

2.Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An, Shandong, Peoples R China

3.Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang, Henan, Peoples R China

关键词： chicken anemia virus; immunosuppressive virus; severe anemia; molecular characteristics; pathogenicity

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：5.7； 五年影响因子：5.9 ）

ISSN： 2235-2988

年卷期： 2023 年 13 卷

页码：

收录情况： SCI

摘要： Chicken infectious anemia (CIA) is caused by chicken anemia virus (CAV). Recently, severe anemia has emerged in layer chickens (8 to 10-week-old) on poultry farms in China. However, the etiological characteristics and pathogenic potential of CAV in chickens at 6 weeks or older are not well understood. In this study, we isolated a CAV strain, termed SD15, from two-month-old chicken with severe anemia and analyzed the genetic evolution relationship. We found that strain SD15 had the highest homology (98.9%) with CAV18 strain. Comparison with 33 reference strains revealed 16 amino acid mutations in strain SD15, two of which were previously unknown (F210S in VP1 and L25S in Vp3). Compared with low pathogenic strains (Cux-1 and C14), highly pathogenic strains (SDLY08 and SD15) had three base mutations in their noncoding region. To further understand its pathogenicity, 10-week-old specific-pathogen-free (SPF) chickens were challenged with the novel strain and SDLY08. No obvious clinical symptoms were observed in the SDLY08 group. However, SD15-infected chickens showed significant growth retardation and immunosuppression. The main manifestations of immunosuppression were the significantly reduced thymus and bursa indices and AIV-H9 vaccine-induced antibody levels (P < 0.05). The lowest number of red blood cells in the SD15 group was just 60% of that in the control group. Taken together, the novel strain SD15 not only showed higher pathogenicity but also exhibited the potential ability to break the age resistance of older chickens to CAV. Our study enhanced the understanding of the epidemiological characteristics of chickens infected with severe anemia and can facilitate the development of improved control strategies of CIA in China.

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