Complete genome and pathogenesis of a novel recombinant Senecavirus A isolate in PR China
文献类型： 外文期刊
作者： Li, Chen 1 ; Wu, Xiaoyan 1 ; Wang, Xiaoli 3 ; Shi, Jianli 1 ; Liu, Chang 1 ; Peng, Zhe 1 ; Han, Hong 1 ; Xu, Shaojian 1 ; Wang, Shuo 1 ; Ma, Yingru 4 ; Zheng, Limei 4 ; Hrabchenko, Nataliia 1 ; Li, Jun 1 ;
作者机构： 1.Shandong Acad Agr Sci, Shandong Prov Key Lab Anim Dis Control & Breeding, Inst Anim Sci & Vet Med, Jinan, Peoples R China
2.Shandong Normal Univ, Coll Life Sci, Jinan, Peoples R China
3.Shandong Agr Univ, Dept Vet Prevent Med, Coll Vet Med, Tai An, Shandong, Peoples R China
4.Qingdao Agr Univ, Qingdao, Peoples R China
关键词： Senecavirus A; full-length genome; pigs; pathogenesis; transmission
期刊名称：JOURNAL OF GENERAL VIROLOGY （ 影响因子：3.8； 五年影响因子：3.8 ）
ISSN： 0022-1317
年卷期： 2022 年 103 卷 11 期
页码：
收录情况： SCI
摘要： Senecavirus A (SVA), formerly called Seneca Valley virus (SVV) was first isolated from the USA in 2002. This study isolated an SVA strain from a pig herd in Shandong Province, PR China and designated it SVA-CH-SDGT-2017. The full-length genome, excluding the poly(A) tails of the SVA isolates, was 7280 nucleotides long, with the genomic organization resembling and sharing high nucleotide identities of 90.7-96.9 % with other previously reported SVA isolates. To investigate the pathogenicity of the SVA isolates, experimental infections of pigs were performed. The SVA strains successfully infected the pigs, as evidenced by the presence of virus shedding and robust serum neutralizing antibody responses. In addition, the contact-exposed experiment showed that the virus shedding of the contact-exposed pigs was approximately a 100-fold reduced compared to that of the inoculated group, indicating that the virus is capable of transmission to pigs. Our findings provide useful data for studying the pathogenesis and transmission of SVA in pigs.
- 相关文献
作者其他论文 更多>>
-
Effects of Substitute Substrate, Water, and Fertilizer Management on the Growth of Potted Chrysanthemums
作者：Lu, Yufan;Zhou, Tongjun;Guo, Jinqing;Zhong, Jian;Li, Dawei;Shi, Huajin;Liu, Chang;Xiang, Ruizi;Sun, Ming;Guo, Jinqing
关键词：potted chrysanthemum; substitute substrates; fertilizers; water
-
Analysis of genetic variations of a recombinant strain derived from the three lineages of porcine reproductive and respiratory syndrome virus-2
作者：Zheng, Limei;Ma, Yingru;Wen, Jianxin;Li, Jun;Han, Xianjie;Wu, Xiaoyan;Liu, Chang;Li, Chen;Shi, Jianli;Han, Hong;Xu, Shaojian;Hrabchenko, Nataliia;Li, Jun;Huang, Mengjie;Qiu, Jianhua
关键词：PRRSV; recombination strains; GP5; NSP2; genetic evolutionary analysis; next-generation sequencing
-
Optimized production of full-length PCV2d virus-like particles in Escherichia coli : A cost-effective and high-yield approach for potential vaccine antigen development
作者：Zhang, Chengxin;He, Fang;Li, Nianfeng;Wen, Jianxin;Han, Xianjie;Li, Jun;Wu, Xiaoyan;Shi, Jianli;Li, Chen;Liu, Chang;Xu, Shaojian;Han, Hong;Hrabchenko, Nataliia;Du, Wei;Li, Jun
关键词：PCV2d; Cap protein; Virus -like particles (VLPs); Escherichia coli expression system; Vaccine development; Immunogenicity
-
Grp94 Inhibitor HCP1 Suppressed the Replication of SVA in BHK-21 Cells and PK-15 Cells
作者：Wang, Shuo;Cui, XiaoLing;Hui, Ren;Yao, Wen;Miao, JunYing;Zhao, BaoXiang;Li, Jun
关键词：Senecavirus A; Grp94; HCP1; Virus replication; Autophagy; Infection; Endoplasmic Reticulum (ER).
-
Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
作者：Hu, Ming;Liu, Zhengjie;Song, Ziang;Li, Lulu;Zhao, Xiaonan;Luo, Yanbo;Zhang, Qing;Chen, Yibao;Xu, Xiaohui;Dong, Yahui;Hrabchenko, Nataliia;Liu, Yuqing;Liu, Zhengjie;Song, Ziang;Zhang, Wei
关键词：
-
Development of SYBR Green I-based quantitative PCR assay for identification of porcine circovirus 1, 2 and 3
作者：Liu, Chang;Tian, Yao;Shi, Jian-Li;Li, Chen;Xu, Shao-Jian;Wu, Xiao-Yan;Han, Hong;Li, Jun;Tian, Yao;Zheng, Li-mei;Ma, Ying-Ru;Li, Jun;Han, Xian-Jie
关键词：porcine circovirus; specificity; sensitivity; SYBR Green I based quantitative PCR; single identification method
-
Novel p22 and p30 dual-proteins combination based indirect ELISA for detecting antibodies against African swine fever virus
作者：Li, Jianda;Jiao, Jian;Liu, Na;Ren, Sufang;Zeng, Hao;Zhang, Yuyu;Guo, Lihui;Liu, Fei;Lv, Tingting;Chen, Zhi;Sun, Wenbo;Hrabchenko, Nataliia;Yu, Jiang;Wu, Jiaqiang;Jiao, Jian;Yu, Jiang;Wu, Jiaqiang;Liu, Na;Zhang, Yuyu;Lv, Tingting;Wu, Jiaqiang;Peng, Jun
关键词：African swine fever virus; indirect ELISA; p22; p30; serological diagnosis
