您好，欢迎访问山东省农业科学院文献资源数据库平台

Epigenetic effect of long-term bisphenol A exposure on human breast adenocarcinoma cells

文献类型： 外文期刊

作者： Wang, Xiaoli 1 ; Wei, Yunbo 2 ; Guo, Tao 3 ; Yuan, Jinpeng 1 ; Zhao, Rusong 1 ;

作者机构： 1.Qilu Univ Technol, Shandong Acad Sci, Key Lab Appl Technol Sophisticated Analyt Instrum, Anal & Test Ctr, Jinan, Shandong, Peoples R China

2.Qilu Univ Technol, Shandong Acad Sci, Anal & Test Ctr, Jinan, Shandong, Peoples R China

3.Shandong Acad Agr Sci, Shandong Rice Res Inst, Jinan, Shandong, Peoples R China

关键词： DNA methylation; bisphenol A; human breast cancer cell; epigenotoxicity

期刊名称：TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY （ 影响因子：1.437； 五年影响因子：1.354 ）

ISSN： 0277-2248

年卷期： 2018 年 100 卷 2 期

页码：

收录情况： SCI

摘要： In this research, epigenetic effects of bisphenol A (BPA) on human breast cancer MCF-7 cells were analyzed. Genome-wide DNA methylation and gene expression were analyzed in MCF-7 cells exposed to BPA (10(-5) and 10(-6)mol/L for 5 weeks). No significant changes in the global level of 5-methyl-2-deoxycytidine and 5-hydroxymethyl-2-deoxycytidine were observed. DNA methylation profiling analysis indicated that BPA exposure resulted in the hypermethylation of FOXK2, LKB1, LMX1A and CUGBP2 and the hypomethylation of PTPRN2, TRIM27, BCAS3 and ZNF423. Decreased expression of apoptosis genes (P38 and BCL2L1) and increased expression of chemokine (Cxcl2 and ccl20) were detected. Changes of these genes were speculated to affect the ER-related cell growth as well as cell apoptosis.

  • 相关文献

[1]Epigenetic effect of long-term bisphenol A exposure on human breast adenocarcinoma cells. Wang, Xiaoli,Yuan, Jinpeng,Zhao, Rusong,Wei, Yunbo,Guo, Tao. 2018

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台