Design, synthesis, and biological activity of novel pomalidomide linked with diphenylcarbamide derivatives
文献类型： 外文期刊
作者： Sun, Bin 3 ; Liu, Xiaofei 1 ; Ji, Tao 1 ; Zhan, Xiaoguang 1 ; Mao, Longfei 1 ; Deng, Peng 1 ; Shi, Lin 2 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Agroprod Proc Technol Shandong Prov, Key Lab Novel Food Resources Proc,Minist Educ, Jinan 250100, Peoples R China
2.Shandong First Med Univ, Shandong Prov Hosp, Dept Ultrasound Diag & Treatment Dept, Jinan 250021, Peoples R China
3.Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ,Shandong Pro, 88 East Wenhua Rd, Jinan 250014, Peoples R China
4.Jinan Asia Pharm Tech Co Ltd, Jinan 250101, Peoples R China
关键词： 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline1,3-dione; pomalidomide; diphenylcarbamide; derivatives; synthesis; IDO1
期刊名称：HETEROCYCLIC COMMUNICATIONS （ 影响因子：2.0； 五年影响因子：1.436 ）
ISSN： 0793-0283
年卷期： 2022 年 28 卷 1 期
页码：
收录情况： SCI
摘要： Based on 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione as a raw material, a series of novel pomalidomide linked with diphenylcarbamide derivatives were synthesized through several step reactions of substitution, click reaction, and addition reaction. The structures of these compounds were confirmed by H-1 NMR, C-13 NMR, and MS. We discovered that some of the compounds are capable of suppressing indoleamine pyrrole-2,3-dioxygenase-1 activities in in vitro experiments, in which the inhibitory activity of 5b reached the level of benefits.
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