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Novel compounds with promising IDO1 inhibitory activity as new cancer drug candidates: Derivatives of N,N'-diphenylurea linked with 1,2,3-triazole

文献类型： 外文期刊

作者： Sun, Bin 1 ; Liu, Xiaofei 2 ; Sun, Xiuwei 2 ; Zhou, Yingjie 4 ; Gong, Xiaoqing 5 ; Mao, Longfei 2 ; Shi, Weichen 2 ; Deng, Peng 2 ; Shi, Lin 7 ;

作者机构： 1.Shandong NormColl Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized Probes Chem, Shandong Prov Key Lab Clean Prod Fine Chemicalsal, Key Lab Mol & Nano Probes,Minist Educ, Jinan, Peoples R China

2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Agroprod Proc Technol Shandong Prov, Key Lab Novel Food Resources Proc,Minist Agr, Jinan 250100, Peoples R China

3.Jinan Asia Pharm Tech Co Ltd, Jinan, Peoples R China

4.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang, Peoples R China

5.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou, Peoples R China

6.Shandong First Med Univ, Dept Thyroid Surg, Affiliated Hosp 1, Jinan, Peoples R China

7.Shandong First Med Univ, Dept Ultrasound Diag, Shandong Prov Hosp, Jinan, Peoples R China

8.Shandong First Med Univ, Shandong Prov Hosp, Treatment Dept, Jinan 250021, Peoples R China

期刊名称：PHARMAZIE （ 影响因子：1.6； 五年影响因子：1.6 ）

ISSN： 0031-7144

年卷期： 2023 年 78 卷 1-4 期

页码：

收录情况： SCI

摘要： To explore potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors, we designed a series of compounds incorporating urea and 1,2,3-triazole structures. IDO1 enzymatic activity experiments with the synthesized compounds were used to verify their molecular-level activity; for instance, the half maximal inhibitory concentra-tion value of compound 3c was 0.07 mu M. Our research has yielded a series of novel IDO1 inhibitors which may be beneficial in the development of drugs targeting IDO1 for cancer treatment.

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