The brain-specific upregulation of CARD11 in response to avian brain- neurotropic virus infection serves as a potential biomarker
文献类型： 外文期刊
作者： Wang, Wenbin 1 ; Zhang, Yajie 2 ; Xiao, Sa 2 ; Liu, Xuelan 1 ; Yan, Peipei 1 ; Fu, Chunyan 1 ; Yang, Zengqi 2 ;
作者机构： 1.Shandong Acad Agr Sci, Poultry Inst, Jinan 250100, Shandong, Peoples R China
2.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China
关键词： CARD11; brain-specific upregulation; avian brain-neurotropic virus; potential biomarker
期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）
ISSN： 0032-5791
年卷期： 2023 年 102 卷 4 期
页码：
收录情况： SCI
摘要： Avian neurotropic viruses are critical problems in poultry industry causing severe central nervous system (CNS) damage with neuroinvasive and neurovirulence properties. Biomarker of neuro-tropic viral intracranial invasion is of great applica-tion value for the diagnosis, but that of avian neurotropic viruses remains elusive. Previously, we found that chicken caspase recruitment domain fam-ily, member 11 (CARD11) was only upregulated in virulent Newcastle disease virus-infected chickens and in chicken primary neuronal cells. In this study, CARD11 was systemically expressed in chickens and pigeons detected by absolute qPCR and immunohis-tochemical (IHC) assay. After virus challenging, only avian neurotropic viruses (avian encephalomyelitis virus [AEV] and pigeon paramyxovirus type 1 [PPMV-1]) except Marek's disease virus (MDV) can invade brain and cause pathological changes. The relative mRNA expression of CARD11 was brain-upregulated in AEV-or PPMV-1-infected animals, rather than MDV and non-neurotropic viruses (fowl adenovirus serotype 4 [FAdV-4] and infectious bron-chitis virus [IBV]). Similarly, the protein expression of CARD11 was only upregulated in the cerebra and cerebella infected by avian brain-neurotropic virus using IHC assay. And there were no correlations between the change level of CARD11 and viral load. Our preliminary data suggested that avian CARD11 may be a potential brain biomarker for avian brain-neurotropic virus invasion.
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