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Preparation of sn-2-acTAG from Polygala seed oil and a study on its hypolipidemic effect

文献类型： 外文期刊

作者： Wang, Qing 1 ; Huang, Chen 1 ; Zhang, Meng-Qi 1 ; Rong, Yao 2 ; Guo, Xu 1 ; Smith, Mark A. 3 ; Liu, Chao 1 ; Sun, Jin-Yue 1 ;

作者机构： 1.Shandong Acad Agr Sci, Key Lab Novel Food Resources Proc, Key Lab Agroprod Proc Technol Shandong Prov, Inst Agrofood Sci & Technol,Minist Agr & Rural Aff, 23788 Gongye North Rd, Jinan 250000, Peoples R China

2.Qingdao Univ, Coll Text & Clothing, 7 Hong Kong East Rd, Qingdao 266071, Peoples R China

3.Agr & Agrifood Canada, Saskatoon Res & Dev Ctr, 107 Sci Pl, Saskatoon, SK S7N 0X2, Canada

关键词： Polygala seed oil; Sn-2-acTAG; Hypolipidemic effect; Toxicity; Mechanism

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2023 年 111 卷

页码：

收录情况： SCI

摘要： A new class of 2-acetyl-1,3-diacyl-sn-glycerols (sn-2-acTAG) was found in the seed oil of Polygala previously. Its structure is very similar to sn-1,3-DAG, which has effect of preventing and treating hyperlipidemia and other diseases. In this study, sn-2-acTAG was enriched and confirmed, the safety and the hypolipidemic activity was assessed. In addition the mechanism of action was investigated. Our study indicated that a diet containing 20% sn-2-acTAG or lower was not toxic to SD rats. Compared to the soybean oil group, sn-2-acTAG could lower the total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels, as well as rise the level of high -density lipoprotein cholesterol. Sn-2-acTAG could regulate the expression of proinflammatory factors to ameliorate hyperlipidemia. In conclusion, sn-2-acTAG has for the first time been found to significantly ameliorate hyperlipidemia in the high-fat diet rat. This study will provide a strong theoretical support for the efficient development and application of Polygala seed oil.

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