PEtN-Modified O-Antigen Enhances Shigella Pathogenesis by Promoting Epithelial Cell Invasion and Inhibiting Complement Binding
文献类型： 外文期刊
作者： Zheng, Ruicheng 1 ; Li, Wan 2 ; Yin, Wenjuan 3 ; Qiao, Lu 1 ; Song, Shikai 4 ; An, Yina 1 ; Ling, Zhuoren 1 ; Bai, Li 5 ; Yang, Hui 5 ; Shen, Jianzhong 1 ; Dong, Yanjun 1 ; Wang, Yang 1 ;
作者机构： 1.China Agr Univ, Coll Vet Med, Natl Key Lab Vet Publ Hlth & Safety, Beijing 100193, Peoples R China
2.Shenzhen Univ, Sch Basic Med, Shenzhen 518055, Guangdong, Peoples R China
3.Hebei Univ, Sch Basic Med, Baoding 071000, Hebei, Peoples R China
4.Shandong Acad Agr Sci, Poultry Inst, Jinan 250100, Shandong, Peoples R China
5.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China
关键词： Shigella flexneri; polysaccharide; O-antigen; virulence; complement
期刊名称：ACS INFECTIOUS DISEASES （ 影响因子：5.3； 五年影响因子：5.1 ）
ISSN： 2373-8227
年卷期： 2024 年 10 卷 2 期
页码：
收录情况： SCI
摘要： Shigellosis poses an ongoing global public health threat. The presence and length of the O-antigen in lipopolysaccharide play critical roles in Shigella pathogenesis. The plasmid-mediated opt gene encodes a phosphoethanolamine (PEtN) transferase that catalyzes the addition of PEtN to the O-antigen of Shigella flexneri serotype X and Y strains, converting them into serotype Xv and Yv strains, respectively. Since 2002, these modified strains have become prevalent in China. Here we demonstrate that PEtN-mediated O-antigen modification in S. flexneri increase the severity of corneal infection in guinea pigs without any adaptive cost. This heightened virulence is associated with epithelial cell adhesion and invasion, as well as an enhanced inflammatory response of macrophage. Notably, PEtN addition allow S. flexneri to attenuate the binding of complement C3 and better resist phagocytosis, potentially contributing to the retention of S. flexneri in the host environment.
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