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PB2 and hemagglutinin mutations confer a virulent phenotype on an H1N2 avian influenza virus in mice

文献类型： 外文期刊

作者： Yu, Zhijun 1 ; Ren, Zhiguang 5 ; Zhao, Yongkun 2 ; Cheng, Kaihui 4 ; Sun, Weiyang 2 ; Zhang, Xinghai 2 ; Wu, Jiaqiang 1 ; He, Hongbin 3 ; Xia, Xianzhu 2 ; Gao, Yuwei 2 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Poultry Sci, 1 Jiaoxiao Rd, Jinan 250023, Shandong, Peoples R China

2.Acad Mil Med Sci, Mil Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, 666 Liuyingxi St, Changchun 130122, Jilin, Peoples R China

3.Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China

4.Shandong Acad Agr Sci, Dairy Cattle Res Ctr, Jinan 250132, Shandong, Peoples R China

5.Henan Univ, Sch Basic Med Sci, Joint Natl Lab Antibody Drug Engn, Kaifeng 475004, Peoples R China

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2019 年 164 卷 8 期

页码：

收录情况： SCI

摘要： We previously obtained mouse-adapted variants of H1N2 avian influenza virus that contained PB2-L134H, PB2-I647L, PB2-D701N, HA-G228S, and M1-D231N mutations. Here, we analyzed the effects of these mutations on viral pathogenicity in a mammalian model. By evaluating the virulence of mouse-adapted H1N2 variants at different generations, we found that the PB2-D701N and HA-G228S mutations both contribute to the virulence of this virus in mammals. Furthermore, we found that the PB2-D701N and HA-G228S mutations both enhance the ability of the virus to replicate in vivo and in vitro and that the PB2-D701N substitution results in an expansion of viral tissue tropism. These results suggest that the PB2-D701N mutation and the HA-G228S mutation are the major mammalian determinants of H1N2 virus. These results help us to understand more about the mechanisms by which influenza viruses adapt to mammals, and monitoring of these mutations can be used in continuous influenza surveillance to assess the pandemic potential of avian influenza virus variants.

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