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Important role of Bacillus subtilis as a probiotic and vaccine carrier in animal health maintenance

文献类型： 外文期刊

作者： Yuan, Chunmei 1 ; Ji, Xiang 1 ; Zhang, Yuyu 2 ; Liu, Xinli 1 ; Ding, Luogang 2 ; Li, Jianda 2 ; Ren, Sufang 2 ; Liu, Fei 2 ; Chen, Zhi 2 ; Zhang, Lin 2 ; Zhu, Wenxing 1 ; Yu, Jiang 2 ; Wu, Jiaqiang 2 ;

作者机构： 1.Qilu Univ Technol, Shandong Acad Sci, Coll Bioengn, State Key Lab Biobased Mat & Green Papermaking LBM, Jinan, Peoples R China

2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China

3.Shandong Normal Univ, Sch Life Sci, Jinan, Peoples R China

关键词： Immunity; Intestinal flora balance; Probiotics; Spore surface display; Vaccine carriers

期刊名称：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY （ 影响因子：4.0； 五年影响因子：4.3 ）

ISSN： 0959-3993

年卷期： 2024 年 40 卷 9 期

页码：

收录情况： SCI

摘要： Bacillus subtilis is a widespread Gram-positive facultative aerobic bacterium that is recognized as generally safe. It has shown significant application value and great development potential in the animal farming industry. As a probiotic, it is frequently used as a feed growth supplement to effectively replace antibiotics due to its favourable effects on regulating the intestinal flora, improving intestinal immunity, inhibiting harmful microorganisms, and secreting bioactive substances. Consequently, the gut health and disease resistance of farmed animals can be improved. Both vegetative and spore forms of B. subtilis have also been utilized as vaccine carriers for delivering the antigens of infectious pathogens for over a decade. Notably, its spore form is regarded as one of the most prospective for displaying heterologous antigens with high activity and stability. Previously published reviews have predominantly focused on the development and applications of B. subtilis spore surface display techniques. However, this review aims to summarize recent studies highlighting the important role of B. subtilis as a probiotic and vaccine carrier in maintaining animal health. Specifically, we focus on the beneficial effects and underlying mechanisms of B. subtilis in enhancing disease resistance among farmed animals as well as its potential application as mucosal vaccine carriers. It is anticipated that B. subtilis will assume an even more prominent role in promoting animal health with in-depth research on its characteristics and genetic manipulation tools.

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