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Characterization, Antioxidant, Anti-Aging and Organ Protective Effects of Sulfated Polysaccharides from Flammulina velutipes

文献类型： 外文期刊

作者： Yuan, Fangfang 1 ; Gao, Zheng 2 ; Liu, Wenbo 2 ; Li, Huaping 2 ; Zhang, Yiwen 2 ; Feng, Yanbo 2 ; Song, Xinling 2 ; Wang, 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Agr Resources & Environm, Key Lab Wastes Matrix Utilizat, Minist Agr, Jinan 250100, Shandong, Peoples R China

2.Shangdong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China

关键词： sulfated polysaccharides; Flammulina velutipes; antioxidation; anti-aging effects; organ protection

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期： 2019 年 24 卷 19 期

页码：

收录情况： SCI

摘要： As an irreversible and complex degenerative physiological process, the treatment for aging seems strategically necessary, and polysaccharides play important roles against aging owing to their abundant bioactivities. In this paper, the antioxidant and anti-aging activities of Flammulina velutipes polysaccharides (FPS) and its sulfated FPS (SFPS) on d-galactose-induced aging mice were investigated. The in vitro antioxidant activities demonstrated that SFPS had strong reducing power and superior scavenging effects on 2, 2-diphenylpicrylhydrazyl (DPPH), hydroxyl radicals and the chelating activities of Fe2+. The in vivo animal experiments manifested that the SFPS showed superior antioxidant and protective abilities against the d-galactose-induced aging by increasing the antioxidant enzyme activities, decreasing lipid peroxidation, improving the inflammatory response and ameliorating the anile condition of mice. Furthermore, the structural analysis of SFPS was investigated through FT-IR, NMR, and HPLC analysis, and the results indicated that SFPS was a homogeneous heteropolysaccharide with a weight-average molecular weight of 2.81 x 10(3) Da. Furthermore, SFPS has also changed in characteristic functional groups and monosaccharide composition compared to FPS. These results suggested that sulfated modification could enhance the anti-oxidation, anti-aging and protective activities of F. velutipes polysaccharides, which may provide references for the development of functional foods and natural medicines.

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