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High Value Utilization of an Avermectin Fermentation Byproduct: Novel B2a Derivatives as Pesticide Candidates

文献类型： 外文期刊

作者： Xu, Qingbo 1 ; Li, Jinming 1 ; Guo, Wenxiu 2 ; Xiang, Juncheng 3 ; Zhou, Liqi 3 ; Zhang, Jianjun 1 ;

作者机构： 1.China Agr Univ, Dept Appl Chem, Coll Sci, Innovat Ctr Pesticide Res, Beijing 100094, Peoples R China

2.Shandong Acad Agr Sci, Inst Plant Protect, Shandong Key Lab Plant Virol, Jinan 250100, Peoples R China

3.Shanghai GreenTech Lab Co Ltd, Shanghai 100093, Peoples R China

关键词： avermectin; ointment; pesticide; B2a; nematicidal activity

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）

ISSN： 0021-8561

年卷期： 2022 年 70 卷 21 期

页码：

收录情况： SCI

摘要： In an effort to develop novel molecules with suitable insecticidal activities, 23,24-alkene-avermectin B2a derivatives have been synthesized via a one-pot multistep reaction using avermectin B2a, a byproduct of avermectin fermentation, as a starting material. All products and intermediates were characterized by H-1 NMR, C-13 NMR, and high-resolution mass spectrometry. Bioassay results showed that the LC50 values of compounds 4 and 9 against Meloidogyne incognita were 0.63 and 0.50 mg/L, respectively, similar to that of avermectin (0.46 mg/L). Importantly, the LC50 values of compound 9 against Tetranychus cinnabarinus and Mythimna separate were 0.0067 and 0.047 mg/L, respectively, superior to that of avermectin. Through field experiments, it could be found that spraying 0.25% water-dispersible granules of compound 9 345 g ha(-1) could effectively control M. incognita outbreaks, with an efficacy of 84.9%. Combined with toxicity experiments, it could be further inferred that compound 9 may be useful as a low-toxicity pesticide. In summary, we efficiently synthesized a new B2a derivative as a potential pesticide and offered an important way for improving the utilization efficiency of avermectin fermentation products. In doing so, the environmental pollution associated with fermentation byproducts may be greatly reduced, potentially enabling a sustainable avermectin fermentation process.

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