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Effect of industrial trans-fatty acids-enriched diet on gut microbiota of C57BL/6 mice

文献类型： 外文期刊

作者： Ge, Yueting 1 ; Liu, Wei 1 ; Tao, Haiteng 3 ; Zhang, Yu 1 ; Liu, Lina 1 ; Liu, Zhenhua 4 ; Qiu, Bin 1 ; Xu, Tongcheng 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Agroprod Proc Technol Shandong Prov, Key Lab Novel Food Resources Proc,Minist Agr, Jinan, Shandong, Peoples R China

2.Jiangnan Univ, Sch Food Sci & Technol, Lab Food Nutr & Funct Factors, Wuxi, Jiangsu, Peoples R China

3.Qilu Univ Technol, Shandong Acad Sci, Coll Food Sci & Engn, State Key Lab Biobased Mat & Green Papermaking, Jinan, Shandong, Peoples R China

4.Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA

关键词： Trans-fatty acid; Gut microbiota; Short-chain fatty acid; 16S rRNA gene sequencing

期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：5.614； 五年影响因子：5.286 ）

ISSN： 1436-6207

年卷期： 2019 年 58 卷 7 期

页码：

收录情况： SCI

摘要： Purpose Previous studies have shown that industrially originated trans-fatty acids (iTFAs) are associated with several chronic diseases, but the underlying mechanisms remain unknown. Because gut microbiota play a critical role in human health, diet competent induced gut microbiota dysbiosis may contributing to disease pathogenesis. Therefore, the present study examined the impact of iTFA on gut microbiota, help understanding the underling mechanism of iTFA-associated chronic diseases. Methods Forty male 8-week-old mice were divided into 4 groups and randomly assigned to diets containing soybean oil (non-iTFA) or partially hydrogenated soybean oil ( iTFA). The intervention groups were: (1) low soybean oil (LS); (2) high soybean oil (HS); (3) low partially hydrogenated oil (LH) and (4) high partially hydrogenated oil ( HH). The gut microbiota profiles were determined by 16S rRNA gene sequencing. Physiological parameters and the inflammatory status of the small intestine and other tissues were analyzed. Short-chain fatty acid levels in feces were measured using gas chromatography. Results The intake of iTFA increased the abundance of well-documented `harmful' bacteria, such as Proteobacteria and Desulfovibrionaceae (P < 0.05), whereas it decreased relative abundance of ` beneficial' bacteria, such as Bacteroidetes, Lachnospiraceae, Bacteroidales S24-7 (P < 0.05). Surprisingly, the intake of iTFA increased the abundance of the probiotic Lactobacillaceae (P < 0.05). Additionally, the intake of iTFA induced increase of inflammatory parameters, as well as a numerical decrease of fecal butyric acid and valeric acid. Conclusions This study, to our knowledge, is the first to demonstrate that the consumption of iTFA resulted in a significant dysbiosis of gut microbiota, which may contribute to the development of chronic diseases associated with iTFA.

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[1]Effect of industrial trans-fatty acids-enriched diet on gut microbiota of C57BL/6 mice. Ge, Yueting,Liu, Wei,Zhang, Yu,Liu, Lina,Qiu, Bin,Xu, Tongcheng,Ge, Yueting,Tao, Haiteng,Liu, Zhenhua. 2019

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