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Deciphering the miRNA transcriptome of breast muscle from the embryonic to post-hatching periods in chickens

文献类型： 外文期刊

作者： Liu, Jie 1 ; Li, Fuwei 1 ; Hu, Xin 4 ; Cao, Dingguo 1 ; Liu, Wei 1 ; Han, Haixia 1 ; Zhou, Yan 1 ; Lei, Qiuxia 1 ;

作者机构： 1.Shandong Acad Agr Sci, Poultry Inst, Jinan 250023, Peoples R China

2.Poultry Breeding Engn Technol Ctr Shandong Prov, Jinan 250023, Peoples R China

3.Shandong Prov Key Lab Poultry Dis Diag & Immunol, Jinan 250023, Peoples R China

4.Minist Agr & Rural Affairs, Key Lab Anim Poultry Genet Breeding & Reprod, Beijing 100193, Peoples R China

5.Univ Liege, Gembloux Agrobio Tech, Mol & Cellular Biol, B-5030 Gembloux, Belgium

关键词： Breast muscle; Muscle development; miRNA transcriptome; Differential expression profiles

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2021 年 22 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundmiRNAs play critical roles in growth and development. Various studies of chicken muscle development have focused on identifying miRNAs that are important for embryo or adult muscle development. However, little is known about the role of miRNAs in the whole muscle development process from embryonic to post-hatching periods. Here, we present a comprehensive investigation of miRNA transcriptomes at 12-day embryo (E12), E17, and day 1 (D1), D14, D56 and D98 post-hatching stages.ResultsWe identified 337 differentially expressed miRNAs (DE-miRNAs) during muscle development. A Short Time-Series Expression Miner analysis identified two significantly different expression profiles. Profile 4 with downregulated pattern contained 106 DE-miRNAs, while profile 21 with upregulated pattern contained 44 DE-miRNAs. The DE-miRNAs with the upregulated pattern mainly played regulatory roles in cellular turnover, such as pyrimidine metabolism, DNA replication, and cell cycle, whereas DE-miRNAs with the downregulated pattern directly or indirectly contributed to protein turnover metabolism such as glycolysis/gluconeogenesis, pyruvate metabolism and biosynthesis of amino acids.ConclusionsThe main functional miRNAs during chicken muscle development differ between embryonic and post-hatching stages. miRNAs with an upregulated pattern were mainly involved in cellular turnover, while miRNAs with a downregulated pattern mainly played a regulatory role in protein turnover metabolism. These findings enrich information about the regulatory mechanisms involved in muscle development at the miRNA expression level, and provide several candidates for future studies concerning miRNA-target function in regulation of chicken muscle development.

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