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Phylogenetic analysis and molecular characterization of the co-infection of the new variant of the porcine epidemic diarrhea virus and the novel porcine kobuvirus isolated from piglets with diarrhea

文献类型： 外文期刊

作者： Wei, Ran 1 ; Shang, Rui 2 ; Cheng, Kaihui 3 ; Wang, Song 4 ; Yuan, Xiaoyuan 1 ; Wu, Jiaqiang 2 ; Yu, Zhijun 1 ;

作者机构： 1.Shandong Acad Agr Sci, Poultry Inst, Jinan 250100, Peoples R China

2.Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China

3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Peoples R China

4.Shandong Univ, Med Integrat & Practice Ctr, Jinan 250012, Peoples R China

关键词： Porcine epidemic diarrhea virus; Porcine kobuvirus; Phylogenetic analysis; Molecular characterization

期刊名称：BRAZILIAN JOURNAL OF MICROBIOLOGY （ 影响因子：2.2； 五年影响因子：2.8 ）

ISSN： 1517-8382

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) is a virus that can cause diarrhea in pigs, resulting in significant economic losses to the pig industry. The mutation of the virus and its co-infection with other enteroviruses leads to poor control of PEDV infection. In this study, we found that the diarrhea outbreak in a pig farm in Shandong Province was mainly caused by PEDV infection. Through high-throughput sequencing, we also detected one other diarrhea-related virus (porcine kobuvirus). In the phylogenetic analysis and molecular characterization of the detected PEDV S gene and PKV, it was found that the S gene of the PEDV strain detected in this study (named SD22-2) had more mutations than the CV777 strain. The highest homology between PKV (named SD/2022/China) detected in this study and other strains was only 89.66%. Based on polyprotein, we divided SD/2022/China strains into a new grouping (designated group 4) and detected recombination signals. In summary, SD22-2 detected in this study is a new PEDV variant strain, and SD/2022/China strain might be a novel PKV strain. We also found the co-infection of the new PEDV variant and the novel PKV isolated from piglets with diarrhea. Our data suggested the importance of continuous surveillance of PEDV and PKV.

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