文献类型： 外文期刊

作者： Li, Shufeng ¹ ; Liao, Wensheng ² ; Chen, Meng ¹ ; Shan, Shiying ¹ ; Song, Yuanlin ³ ; Zhang, Shuzhen ³ ; Song, Haihan; ¹ ;

作者机构： 1.Shandong Qianfoshan Hosp, Dept Orthoped, Jinan 250014, Shandong, Peoples R China

2.Zhengzhou Univ, Dept Orthoped, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

3.Shandong Acad Agr Sci, Jinan 250100, Shandong, Peoples R China

4.Tongji Univ, Shanghai East Hosp, Emergency Ctr, Dept Internal Med, Shanghai 200120, Peoples R China

关键词： programmed death-1;T cells;rheumatoid arthritis

期刊名称：INFLAMMATION （ 影响因子：4.092； 五年影响因子：3.923 ）

ISSN： 0360-3997

年卷期： 2014 年 37 卷 1 期

页码：

收录情况： SCI

摘要： Rheumatoid arthritis (RA) is characterized by chronic inflammatory process that targets the synovial lining of diarthrodial joints. Programmed death 1 (PD-1) plays a key role in the negative regulation of the immune response. In the current study, we investigated the expression of PD-1 on peripheral CD4+ and CD8+ T cells in RA patients. Percentage of PD-1+ cells was measured by flow cytometry in 82 RA cases and 90 healthy controls. Results showed that PD-1 expression was significantly decreased in both peripheral CD4+ and CD8+ T cells in RA (p = 0.002 and p < 0.001, respectively). Similarly, serum levels of soluble PD-1 were also downregulated in RA cases. When comparing PD-1 level in RA patients with different clinical parameters, patients with positive C-reactive protein (CRP) revealed lower proportion of PD-1 on CD4+ and CD8+ T cells than those with negative CRP. Also, disease activity score of RA patients was inversely correlated with PD-1 expression on peripheral CD4+ and CD8+ T cells. These data suggested that PD-1 may act as a negative regulator in the pathogenesis and progression of RA.